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Cerebral angiography delineated an avascular frontal or temporal lesion in all 6 patients; in 1 case a magnification study revealed narrowing, irregularity, and occlusion of small cortical vessels. Four of our 6 patients underwent craniotomy with partial or complete surgical extirpation of necrotic brain tissue. Two operated patients are alive and without disabling neurological symptoms 30 and 25 months, respectively, after the operation. The characteristic neuropathological features of delayed radiation necrosis of brain suggest that vascular injury rather than neuronal or glial damage is of primary pathogenetic significance.<\/jats:p>","DOI":"10.1002\/ana.410010406","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:28:42Z","timestamp":1104539322000},"page":"339-357","source":"Crossref","is-referenced-by-count":93,"title":["Cerebral necrosis following radiotherapy of extracranial neoplasms"],"prefix":"10.1002","volume":"1","author":[{"given":"David A.","family":"Rottenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman L.","family":"Chernik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. F. 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