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The capillaries of the first four of these tissue types exhibit blood\u2010brain barrier (BBB) characterisitcs of permeability and capillary ultrastructure and were found to have mitochondrial contents amounting to 8 to 11% of the endothelial cytoplasmic volume. Tissues from non\u2010BBB regions were determined to have mitochondrial volumes of 2 to 5% of their respective cytoplasmic volumes, with a variety of capillary ultrastructures. The apparent excess metabolic work capability of the BBB suggested by this greater number of mitochondria may be related to maintenance of ion differentials between blood plasma and brain extracellular fluid, to extrachoroidal cerebrospinal fluid formation, or to maintaining the unique structural characteristics of central nervous system capillaries.<\/jats:p>","DOI":"10.1002\/ana.410010502","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T19:18:52Z","timestamp":1104520732000},"page":"409-417","source":"Crossref","is-referenced-by-count":589,"title":["The large apparent work capability of the blood\u2010brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat"],"prefix":"10.1002","volume":"1","author":[{"given":"William H.","family":"Oldendorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia E.","family":"Cornford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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