{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:31:46Z","timestamp":1757543506593},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":10021,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1977,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two patients with biopsy\u2010proved progressive multifocal leukoencephalopathy (PML) were treated with near\u2010maximal doses of adenine arabinoside (Ara\u2010A), 18.6 and 20 mg per kilogram of body weight per day for 14 days. In both patients, clinical progression of the disease was correlated with an increase in the size of low\u2010density lesions seen by computerized tomography. One of the patients was observed to excrete abnormal epithelial cells into the urine. These cells contained papovaviruslike particles, and JC virus was cultured from the urine sediment. The relative number of these abnormal cells declined during Ara\u2010A treatment. Both patients died shortly after the conclusion of therapy without a change in the progression of the central nervous system disease. Systemic administration of Ara\u2010A did not offer significant clinical benefit in the treatment of these 2 advanced cases of PML.<\/jats:p>","DOI":"10.1002\/ana.410010509","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:18:52Z","timestamp":1104538732000},"page":"458-462","source":"Crossref","is-referenced-by-count":45,"title":["Adenine arabinoside in the treatment of progressive multifocal leukoencephalopathy: Use of virus\u2010containing cells in the urine to assess response to therapy"],"prefix":"10.1002","volume":"1","author":[{"given":"Kenneth H.","family":"Rand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth P.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucien J.","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry S.","family":"Wolinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Penney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duard L.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billie L.","family":"Padgett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Merigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/81.1.93"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196601000-00007"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.3.205"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1001\/jama.1973.03230020036009","article-title":"Progressive multifocal leukoencephalopathy and cytarabine: remission with treatment","volume":"226","author":"Bauer WR","year":"1973","journal-title":"JAMA"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.229.10.1313"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197205112861909"},{"key":"e_1_2_1_8_2","first-page":"73","article-title":"5 Iodo 2\u2032 deoxyuridine (IUDR; NSG\u201039661) given intraventricularly in the treatment of progressive multifocal leukoencephalopathy","volume":"57","author":"Tarsy D","year":"1973","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1542\/peds.55.5.678","article-title":"Antiviral chemotherapy and neonatal herpes simplex virus infection: a pilot study\u2014experience with adenine arabinoside (ARA\u2010A)","volume":"55","author":"Ch'ien LT","year":"1975","journal-title":"Pediatrics"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/130.1.32"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1148\/122.1.137"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90981-7"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91776-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5876.371"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410010509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410010509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T11:33:01Z","timestamp":1698924781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410010509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,5]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1977,5]]}},"alternative-id":["10.1002\/ana.410010509"],"URL":"https:\/\/doi.org\/10.1002\/ana.410010509","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,5]]}}}