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Concentrations of ALA that inhibit GABA receptor binding are consistent with levels of ALA thought to exist in the central nervous system of porphyric patients. Some of the symptoms of acute porphyria resemble those elicited by muscimol, a potent GABA agonist drug. Barbiturates, which exacerbate porphyric symptoms, are potent facilitators of the synaptic actions of GABA. The results suggest that some symptoms of acute porphyria might be attributable to a mimicking by ALA of GABA at its central nervous system receptor sites.<\/jats:p>","DOI":"10.1002\/ana.410020415","type":"journal-article","created":{"date-parts":[[2004,12,31]],"date-time":"2004-12-31T22:52:27Z","timestamp":1104533547000},"page":"340-342","source":"Crossref","is-referenced-by-count":88,"title":["\u03b4\u2010Aminolevulinic acid: Influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria"],"prefix":"10.1002","volume":"2","author":[{"given":"Walter E.","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon H.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1974.tb10754.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.11.2725"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238666"},{"key":"e_1_2_1_5_2","first-page":"120","article-title":"The acute porphyria attack: III. 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