{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T05:10:08Z","timestamp":1696741808515},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":9656,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1978,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The selective reduction of PAM cell yield reported by Carp and associates in the presence of tissue from patients with multiple sclerosis (MS) has been attributed to replication in culture of a viral agent associated with MS (MSAA). We investigated the diagnostic potential of the PAM cell effect in MS and in optic neuritis (ON). Six serum and 7 CSF samples from 7 patients with MS, 3 serum and 3 CSF samples from 4 patients with idiopathic ON, and 4 sera from 4 patients with ON induced by ethambutal toxicity were tested. Blind counting showed no reduction in PAM cell yield in the MS group nor any significant difference between the two ON groups. Disturbing inconsistencies in PAM cell growth rates over time and between control flasks were demonstrated.<\/jats:p>","DOI":"10.1002\/ana.410030506","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:06:44Z","timestamp":1104584804000},"page":"400-402","source":"Crossref","is-referenced-by-count":1,"title":["Appraisal of the PAM cell effect as a diagnostic test for multiple sclerosis"],"prefix":"10.1002","volume":"3","author":[{"given":"Howard","family":"Cohn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f4el","family":"Oger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Sabouraud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Ardouin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(74)90078-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/247217a0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1966.tb45517.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1128\/iai.11.4.737-741.1975","article-title":"Multiple sclerosis\u2013induced reduction in the yield of a mouse cell line","volume":"11","author":"Carp RI","year":"1975","journal-title":"Infect Immun"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.3.618"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1128\/iai.9.6.1011-1015.1974","article-title":"Reduced cell yields of mouse cell line cultures after exposure to homogenates of multiple sclerosis tissues","volume":"9","author":"Carp RI","year":"1974","journal-title":"Infect Immun"},{"key":"e_1_2_1_8_2","first-page":"191","article-title":"N\u00e9vrite optique par \u00e9thambutol","volume":"46","author":"Deodati F","year":"1974","journal-title":"Rev Otoneuroophthalmol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.39.3.283"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1128\/iai.12.6.1355-1366.1975","article-title":"Multiple sclerosis\u2010associated agent: transmission to animals and some properties of the agent","volume":"12","author":"Koldovsky U","year":"1975","journal-title":"Infect Immun"},{"key":"e_1_2_1_11_2","first-page":"231","article-title":"Studies on the natural history of multiple sclerosis: I. 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