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The syndrome was short lived and always occurred early in the course of treatment. Prolonged neurological deficits remained in 2 patients. When similar chemotherapy was reinstituted in the 4 patients, no further neurological complications ensued. Possible causes include a leukoencephalopathy related to methotrexate or an embolic cerebral vasculopathy related to necrotic tumor microemboli emanating from the lungs.<\/jats:p>","DOI":"10.1002\/ana.410030515","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:06:44Z","timestamp":1104584804000},"page":"441-444","source":"Crossref","is-referenced-by-count":52,"title":["Transient cerebral dysfunction following chemotherapy for osteogenic sarcoma"],"prefix":"10.1002","volume":"3","author":[{"given":"Jeffrey C.","family":"Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"77","article-title":"Toxic effects of intrathecal methotrexate (IT MTX) in central nervous system (CNS) prophylaxis of leukemic children: clinical and morphologic studies","volume":"15","author":"Geiser CF","year":"1974","journal-title":"Proc Am Assoc Cancer Res"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830010204"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.47.253.344"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80533-5"},{"key":"e_1_2_1_6_2","first-page":"779","article-title":"High dose methotrexate with citrovorum factor rescue: predictive value of serum methotrexate concentrations, and corrective measures to avert toxicity","volume":"61","author":"Nirenberg A","year":"1977","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_7_2","first-page":"305","article-title":"Abnormal computed tomography (CT) scans in children with acute lymphocytic leukemia (ALL) following CNS prophylaxis","volume":"18","author":"Peylan\u2010Ramu N","year":"1977","journal-title":"Proc Am Assoc Cancer Res"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197502)35:2<306::AID-CNCR2820350203>3.0.CO;2-J"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000398253"},{"key":"e_1_2_1_10_2","first-page":"681","article-title":"High dose methotrexate with citrovorum factor rescue for the treatment of central nervous system tumors in children","volume":"61","author":"Rosen G","year":"1977","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.230.8.1149"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197503)35:3 <936::AID-CNCR2820350714>3.0.CO;2-B"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197503)35:3<622::AID-CNCR2820350313>3.0.CO;2-C"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490200044005"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V34.3.301.301"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197407112910205"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410030515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410030515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T08:58:21Z","timestamp":1696669101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410030515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,5]]}},"alternative-id":["10.1002\/ana.410030515"],"URL":"https:\/\/doi.org\/10.1002\/ana.410030515","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,5]]}}}