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Replacement therapy with thyroxine and prednisone induced complete remission of the neurological abnormalities. The association of spastic paraplegia with hypothalamic insufficincy has not been reported previously. The possibility of hypothalamic disease should be considered in cases of spastic paraplegia of unknown cause.<\/jats:p>","DOI":"10.1002\/ana.410030520","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:06:44Z","timestamp":1104584804000},"page":"458-461","source":"Crossref","is-referenced-by-count":3,"title":["Hypothalamic hypothyroidism causing spastic paraplegia: Recovery following thyroid medication"],"prefix":"10.1002","volume":"3","author":[{"given":"Ivor M. 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