{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T15:33:20Z","timestamp":1726068800016},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":9595,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1978,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A possible association between the Gilles de la Tourette and Lesch\u2010Nyhan syndromes has recently been postulated. Fourteen patients with Tourette syndrome demonstrated no similarity to Lesch\u2010Nyhan based upon patterns of inheritance, behavioral changes, or alterations of purine metabolism. Despite a strong male predominance, a sex\u2010linked pattern of inheritance could not be confirmed. Self\u2010mutilating behavior was found in 4 male patients but was readily differentiated from that characteristic of the Lesch\u2010Nyhan syndrome. Quantitation of hypoxanthineguanine phosphoribosyltransferase and isoelectric focusing of its isoenzymes produced results that were indistinguishable from those in controls. We speculate that, pathophysiologically, Tourette syndrome represents an imbalance between the central neurotransmitters dopamine and serotonin rather than an alteration in purine metabolism.<\/jats:p>","DOI":"10.1002\/ana.410040105","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:45:22Z","timestamp":1104597922000},"page":"21-25","source":"Crossref","is-referenced-by-count":22,"title":["Gilles de la Tourette syndrome: Further studies and thoughts"],"prefix":"10.1002","volume":"4","author":[{"given":"Harvey S.","family":"Singer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Pepple","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann L.","family":"Ramage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian J.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"7398","DOI":"10.1016\/S0021-9258(19)45899-7","article-title":"Human hypoxanthine\u2010guanine phosphoribosyltransferase","volume":"246","author":"Arnold WJ","year":"1971","journal-title":"J Biol Chem"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00485733"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/233272a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.27.2.115"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.113.499.607"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.122.6.655"},{"key":"e_1_2_1_8_2","first-page":"158","article-title":"Etude sur une affection nerveuse, caracteris\u00e9e par de l'incoordination motrice, accompagn\u00e9e d'\u00e9cholalie et de coprolalie","volume":"9","author":"Gilles de la Tourette G","year":"1885","journal-title":"Arch Neurol (Paris)"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1977.02120180045008"},{"key":"e_1_2_1_10_2","first-page":"260","article-title":"Tics and Tourette's: a continuum of symptoms? 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