{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:05:37Z","timestamp":1790186737144,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":9595,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1978,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifty\u2010two patients with acute and subacute transverse myelopathy (TM) were evaluated at the Massachusetts General Hospital between 1955 and 1975 and followed for 1 to 23 years (average, 5). Nineteen had symptoms of a recent acute infectious illness, 3 had cancer, and 1 had undergone a recent operation. There were four types of initial symptom. Twenty\u2010four patients had paresthesias at the onset of the illness, 18 had pain, usually interscapular, 7 had leg weakness, and 3 had urine retention. Prognosis depended on the nature of the onset of TM. An acute catastrophic onset was generally associated with back pain and led to a poor outcome in 7 and a good outcome in only 1 of 11 patients. A subacute progressive onset over several days to four weeks, generally with ascending paresthesias or leg weakness, was associated with a good outcome in 15 and fair outcome in 17 of 37 patients. Preceding febrile illness, treatment with corticosteroids, and the nature of CSF abnormalities had no effect on outcome. Multiple sclerosis evolved in 7 patients during the follow\u2010up period. Because of the frequency with which mass lesions were missed, the need for myelography in the diagnosis of TM is emphasized.<\/jats:p><jats:p>The distinguishing clinical characteristics of TM provide guidelines for diagnosis and prognosis.<\/jats:p>","DOI":"10.1002\/ana.410040110","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:45:22Z","timestamp":1104597922000},"page":"51-59","source":"Crossref","is-referenced-by-count":130,"title":["The prognosis of acute and subacute transverse myelopathy based on early signs and symptoms"],"prefix":"10.1002","volume":"4","author":[{"given":"Allan H.","family":"Ropper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Poskanzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(52)90234-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1963.00460080021002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)92953-2"},{"key":"e_1_2_1_5_2","first-page":"1447","article-title":"Case records of the Massachusetts General Hospital","volume":"294","year":"1976","journal-title":"N Engl J Med"},{"key":"e_1_2_1_6_2","first-page":"57","volume-title":"Wolff's Headache and Other Head Pain","author":"Dalessio DJ","year":"1972"},{"key":"e_1_2_1_7_2","first-page":"1","article-title":"La my\u00e9lite n\u00e9crotique","volume":"2","author":"Foix C","year":"1926","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/62.3.227"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/78.3.377"},{"key":"e_1_2_1_10_2","first-page":"175","article-title":"Acute myelitis: syndrome of occlusion of the anterior spinal artery at the first thoracic segment with softening of the cord","volume":"40","author":"Hogan BW","year":"1942","journal-title":"US Nav Med Bull"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490290049004"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490220060009"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/87.4.639"},{"key":"e_1_2_1_14_2","volume-title":"Multiple Sclerosis: A Reappraisal","author":"McAlpine D","year":"1968"},{"key":"e_1_2_1_15_2","first-page":"427","article-title":"Parainfectious encephalomyelitis and related syndromes: a critical review of the neurologic complications of certain fevers","volume":"25","author":"Muller HG","year":"1956","journal-title":"Q J Med"},{"key":"e_1_2_1_16_2","first-page":"151","article-title":"Transverse myelopathy in childhood","volume":"85","author":"Paine RS","year":"1953","journal-title":"AMA Arch Dis Child"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/84.3.460"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-60-1-114"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.2.1-2.15"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195801\/02)11:1<76::AID-CNCR2820110116>3.0.CO;2-D"},{"key":"e_1_2_1_21_2","volume-title":"Venous abnormalities, in The Vascular Abnormalities and Tumors of the Spinal Cord and Its Membranes","author":"Wyburn\u2010Mason R","year":"1944"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410040110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410040110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T06:43:24Z","timestamp":1698907404000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410040110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,7]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,7]]}},"alternative-id":["10.1002\/ana.410040110"],"URL":"https:\/\/doi.org\/10.1002\/ana.410040110","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,7]]}}}