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In an unusual case of staphylococcal meningitis associated with a blunted CSF pleocytosis and a poor clinical response to antibiotics, an inhibitor of leukocyte chemotaxis was identified in the CSF. This inhibitor may have diminished local leukocyte accumulation in vivo and thereby adversely affected host defence mechanisms and clinical outcome. No inhibitors were found in other CSF samples tested. Soluble mediators present in CSF may modulate the local accumulation of leukocytes and therefore affect host defenses in meningitis.<\/jats:p>","DOI":"10.1002\/ana.410050403","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:52:56Z","timestamp":1104587576000},"page":"322-326","source":"Crossref","is-referenced-by-count":16,"title":["Substances which modulate leukocyte migration are present in CSF during meningitis"],"prefix":"10.1002","volume":"5","author":[{"given":"David J.","family":"Wyler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen I.","family":"Wasserman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolf W.","family":"Karchmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4049\/jimmunol.115.1.18","article-title":"Physicochemical characterization of chemotactic lymphokines produced by human T and B lymphocytes","volume":"115","author":"Altman LC","year":"1975","journal-title":"J Immunol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.4049\/jimmunol.117.5_Part_2.1866","article-title":"Activation of the alternative pathway of the complement system by radiographic contrast media","volume":"117","author":"Arroyave CM","year":"1976","journal-title":"J Immunol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107287"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.6.1564"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0025-7125(16)32290-8","article-title":"Disorders of host defense against infection: pathophysiologic and diagnostic considerations","volume":"57","author":"Johnson RB","year":"1973","journal-title":"Med Clin North Am"},{"key":"e_1_2_1_7_2","first-page":"190","article-title":"Partial characterization of a cell\u2010directed inhibitor of leukotaxis in human serum","volume":"89","author":"Maderazo EG","year":"1977","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-150-38989"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"857","DOI":"10.4049\/jimmunol.108.3.857","article-title":"Human mononuclear leukocyte chemotaxis: a quantitative assay for humoral and cellular chemotactic factors","volume":"108","author":"Snyderman RL","year":"1972","journal-title":"J Immunol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4049\/jimmunol.102.1.93","article-title":"A neutrophil chemotactic factor from human C5","volume":"102","author":"Ward PA","year":"1969","journal-title":"J Immunol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197402212900802"},{"key":"e_1_2_1_12_2","volume-title":"Chemotaxis and Inflammation","author":"Wilkinson PC","year":"1974"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-2-293"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410050403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410050403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T18:01:36Z","timestamp":1698948096000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410050403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,4]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,4]]}},"alternative-id":["10.1002\/ana.410050403"],"URL":"https:\/\/doi.org\/10.1002\/ana.410050403","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,4]]}}}