{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:49:07Z","timestamp":1792673347875,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":9321,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1979,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Complete global ischemia was produced in 39 dogs by temporary ligation of the aorta. Prior to the ischemic episode, pentobarbital (30 to 45 mg per kilogram of body weight) was administered to 19 of these dogs. The neurological effects of cerebral ischemia episodes lasting 8, 9, or 10 minutes were compared in dogs treated with pentobarbital and those not treated. At 48 hours following the ischemic episode most of the dogs made ischemic for 8 minutes were normal, whereas most animals made ischemic for 10 minutes were dead or comatose. The 9\u2010minute ischemic period resulted in a relatively even distribution of normal and damaged dogs. There were no differences between treated and untreated dogs. Cerebral blood flow, cerebral metabolic rate for oxygen, and various cerebral metabolites were measured in dogs surviving 48 hours. Again, there were no differences between treated and untreated dogs. We conclude that barbiturates provide no protection in this model of complete global ischemia. This conclusion supports the hypothesis that the likely mechanism of barbiturate protection in models of incomplete ischemia or hypoxia is based on cerebral metabolic depression; such a mechanism would not be expected to be effective in complete global ischemia.<\/jats:p>","DOI":"10.1002\/ana.410050407","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:52:56Z","timestamp":1104587576000},"page":"343-349","source":"Crossref","is-referenced-by-count":88,"title":["No barbiturate protection in a dog model of complete cerebral ischemia"],"prefix":"10.1002","volume":"5","author":[{"given":"Petter A.","family":"Steen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.","family":"Milde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Michenfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"BleyaertA NemotoEM SafarP et al: Thiopental amelioration of brain damage after global ischemia in monkeys.Anesthesiology(in press)"},{"key":"e_1_2_1_3_2","unstructured":"BleyaertA StezoskiSW NemotoE et al: Augmentation of postischemic encephalopathy by repetitive arterial hypertension in monkeys inAbstract of the Annual Meeting of the American Society of Anesthesiologists 1977 pp81\u201382"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90102-0"},{"key":"e_1_2_1_5_2","first-page":"276","volume-title":"Elementary Statistics with Applications in Medicine and the Biological Sciences","author":"Croxton FE","year":"1959"},{"key":"e_1_2_1_6_2","first-page":"152","volume-title":"Cerebral Function, Metabolism and Circulation","author":"Demopoulos HB","year":"1977"},{"key":"e_1_2_1_7_2","first-page":"150","volume-title":"Cerebral Function, Metabolism and Circulation","author":"Flamm ES","year":"1977"},{"key":"e_1_2_1_8_2","first-page":"138","article-title":"Increased tolerance to cerebral anoxia by pentobarbital","volume":"161","author":"Goldstein A","year":"1966","journal-title":"Arch Int Pharmacodyn"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1152\/ajplegacy.1972.223.5.1158","article-title":"Metabolism and function of dog's brain recovering from longtime ischemia","volume":"223","author":"Hinzen DH","year":"1972","journal-title":"Am J Physiol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490300037004"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0022-5223(19)42797-9","article-title":"The effect of profound hypothermia on preservation of cerebral ATP content during circulatory arrest","volume":"56","author":"Kramer RS","year":"1968","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(74)91050-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)51740-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1956.01270190100011"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197409000-00004"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(68)90111-X"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500050031006"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197010000-00013"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.8.5.558"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1971.tb07479.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1975.tb05408.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.9.4.335"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.5.1.1"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.9.2.140"},{"key":"e_1_2_1_25_2","unstructured":"SteenPA MichenfelderJD: Barbiturate protection in tolerant and non\u2010tolerant hypoxic mice; 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