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Significant increases occurred in serum alkaline phosphatase and 1\u03b1,25\u2010dihydroxycholecalciferol, in urinary hydroxyproline, and in the fractional gastrointestinal absorption of calcium. Urinary cyclic adenosine monophosphate and serum parathyroid hormone did not change.<\/jats:p><jats:p>The results suggest that the bone disease resulting from phenytoin therapy may be associated with a deficiency of 25\u2010hydroxycholecalciferol and not of 1\u03b1,25\u2010dihydroxycholecalciferol, and that reduced gastrointestinal absorption of calcium or changes in parathyroid function may not be necessary for the development of bone disease.<\/jats:p>","DOI":"10.1002\/ana.410050411","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:52:56Z","timestamp":1104587576000},"page":"374-378","source":"Crossref","is-referenced-by-count":48,"title":["Effect of phenytoin on bone and vitamin D metabolism"],"prefix":"10.1002","volume":"5","author":[{"given":"Rodney D.","family":"Bell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Y. 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