{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:18:32Z","timestamp":1782998312510,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":9260,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1979,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two members of a family with a neuropathy resembling Charcot\u2010Marie\u2010Tooth disease were unable to relax their muscles after voluntary contraction. Muscle spasm often outlasted voluntary contraction by 30 seconds or more before subsiding into myokymia and fasciculations. The posture of the hand during muscle spasm resembled that of tetany, and Trousseau's and Chvostek's signs were present although no abnormality of calcium or magnesium metabolism could be demonstrated. Muscle spasms ceased during medication with carbamazepine, 600 mg daily.<\/jats:p><jats:p>Nerve stimulation, electromyography, and regional neuromuscular blockade with curare indicated that the condition originated in peripheral nerve, while microneurographic recordings showed that sensory as well as motor fibers were hyperexcitable. Sural nerve biopsy revealed axonal degeneration involving myelinated and unmyelinated fibers. It was concluded that the neural hyperexcitability is caused by a membrane defect resulting in a low threshold for excitation throughout the length of the axon.<\/jats:p>","DOI":"10.1002\/ana.410050605","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:51:26Z","timestamp":1104598286000},"page":"523-532","source":"Crossref","is-referenced-by-count":74,"title":["Hyperexcitability of motor and sensory neurons in neuromyotonia"],"prefix":"10.1002","volume":"5","author":[{"given":"James W.","family":"Lance","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(69)91417-5"},{"key":"e_1_2_1_3_2","first-page":"277","article-title":"Une observation de pseudomyotonie gu\u00e9rie par la carbamazepine","volume":"120","author":"Bady B","year":"1969","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00212926"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490170045007"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(66)90026-8"},{"key":"e_1_2_1_7_2","first-page":"825","volume-title":"Peripheral Neuropathy","author":"Dyck PJ","year":"1975"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1959.tb07573.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)91138-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.3.263"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(70)90183-6"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.32.1.11"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.24.4.319"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.30.2.126"},{"key":"e_1_2_1_15_2","first-page":"430","article-title":"Neuromyotonie ou la maladie des fasciculations","volume":"120","author":"Kaeser HE","year":"1969","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1970.tb04783.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500280016003"},{"key":"e_1_2_1_18_2","first-page":"771","volume-title":"Peripheral Neuropathy","author":"Marsden CD","year":"1975"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01712058"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.8.2.140"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690643"},{"key":"e_1_2_1_22_2","first-page":"361","article-title":"Pre\u2010 and postjunctional effects of diphenylhydantoin at the cat soleus neuromuscular junction","volume":"153","author":"Raines A","year":"1966","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1952.02320200074009"},{"key":"e_1_2_1_24_2","first-page":"1003","article-title":"Pseudomyotonie. Forme particuli\u00e8re d'hypertonie musculaire \u00e0 pr\u00e9dominance distale","volume":"115","author":"Sigwald J","year":"1966","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1954.02330060062009"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01652061"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(72)90213-1"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1966.tb01121.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(68)90041-1"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480230048005"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.22.2.161"},{"key":"e_1_2_1_32_2","first-page":"1943","volume-title":"Neurology","author":"Wilson SAK","year":"1955"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/79.2.349"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410050605","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410050605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T17:39:14Z","timestamp":1698946754000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410050605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1979,6]]}},"alternative-id":["10.1002\/ana.410050605"],"URL":"https:\/\/doi.org\/10.1002\/ana.410050605","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,6]]}}}