{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T10:44:33Z","timestamp":1779273873045,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":9260,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1979,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An unusual case of spongiform encephalopathy was transmitted directly from a human to rats and mice. After serial passages, incubation periods were shortened to about six months in rats and four months in mice. Clinical symptoms were similar in rats and mice, including ruffled fur, arched back, bradykinesia, and hind limb paralysis. Pathologically, a spongy state, proliferation of astrocytes, and neuronal changes were observed. Electron microscopic observation of the parietal cortex of rats and mice disclosed many membrane\u2010bound vacuoles in the neuropil, predominantly in dendrites. In the pons of mice, intramyelinic vacuoles and accumulation of extracellular fluid were prominent. The clinicopathological symptoms of the affected animals resembled those in other experimental spongiform encephalopathies, especially scrapie.<\/jats:p>","DOI":"10.1002\/ana.410050616","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:51:26Z","timestamp":1104598286000},"page":"581-584","source":"Crossref","is-referenced-by-count":151,"title":["Transmission of chronic spongiform encephalopathy with kuru plaques from humans to small rodents"],"prefix":"10.1002","volume":"5","author":[{"given":"Jun","family":"Tateishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiya","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshigoro","family":"Kuroiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197404000-00007"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90102-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)92008-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/209794a0"},{"key":"e_1_2_1_6_2","first-page":"383","article-title":"Transmission and characterization of the agents of spongiform virus encephalopathies: Kuru, Creutzfeldt\u2010Jakob disease, scrapie and mink encephalopathy","volume":"49","author":"Gibbs CJ","year":"1971","journal-title":"Res Publ Assoc Res Nerv Ment Dis"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.161.3839.388"},{"key":"e_1_2_1_8_2","first-page":"231","article-title":"An autopsy case of Creutzfeldt\u2010Jakob disease with kuru\u2010like neuropathological changes","volume":"27","author":"Hirano T","year":"1977","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196907000-00001"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197101000-00004"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103289"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91959-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/271778a0"},{"key":"e_1_2_1_14_2","unstructured":"NakamuraT ShidaK TakamatsuI et al:A case of subacute spongiform encephalopathy with many kuru plaque\u2010like structures. Presented at the 19th Congress of the Japanese Society for Neuropathology May 26 1978"},{"key":"e_1_2_1_15_2","first-page":"362","article-title":"A peculiar case of panencephalopathy with widespread distribution of plaques, status spongiosus and demyelination","volume":"20","author":"Nakashima K","year":"1976","journal-title":"Adv Neurol Sci (Tokyo)"},{"key":"e_1_2_1_16_2","first-page":"487","article-title":"An autopsy report of spongiform encephalopathy associated with kuru plaques and leukomalacia","volume":"22","author":"Ohta M","year":"1978","journal-title":"Adv Neurol Sci (Tokyo)"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410050616","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410050616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T17:40:00Z","timestamp":1698946800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410050616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1979,6]]}},"alternative-id":["10.1002\/ana.410050616"],"URL":"https:\/\/doi.org\/10.1002\/ana.410050616","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,6]]}}}