{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:52:50Z","timestamp":1783947170729,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":9168,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1979,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lorazepam, a dichloro\u20103\u2010hydroxy\u20101,4\u2010benzodiazepine, has been shown to be a potent anticonvulsant in animal models of epilsepsy and has minimal depressant effects on respiration and circulation in humans. The effects of this compound were studied in status epilepticus. Twenty\u2010five patients were given intravenous lorazepam during status epilepticus of varying cause. Four or 8 mg of the drug controlled status in 22 of the 25 patients. Although single seizures recurred in 5 of the 22 patients, none experienced recurrence of status during a prolonged follow\u2010up period. Transient respiratory arrest occurred in 1 patient, but no other significant complications were observed. Studies of plasma drug levels suggest that most patients attain good seizure control at concentrations between 30 and 100 ng per milliliter. Clinical observations indicate that repetitive injections are not required for continuing control of seizures in patients whose seizures are initially controlled. Lorazepam appears to be an effective and safe drug for treatment of status epilepticus, with a duration of control longer than that achieved with diazepam.<\/jats:p>","DOI":"10.1002\/ana.410060305","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:55:02Z","timestamp":1104598502000},"page":"207-213","source":"Crossref","is-referenced-by-count":76,"title":["Lorazepam in status epilepticus"],"prefix":"10.1002","volume":"6","author":[{"given":"Jonathan E.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Homan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Vasko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac L.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney D.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Tasker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5637.159"},{"key":"e_1_2_1_3_2","first-page":"216","article-title":"Pharmacology of parenterally administered lorazepam in man","volume":"1","author":"Comer WH","year":"1973","journal-title":"J Int Med Res"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5703.239-b"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1971123468"},{"key":"e_1_2_1_6_2","first-page":"S2","article-title":"Clinical and EEG classifications of seizures","volume":"10","author":"Gastaut H","year":"1969","journal-title":"Epilepsia"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1977.tb05641.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-197310000-00004"},{"key":"e_1_2_1_9_2","first-page":"12","volume-title":"Benzodiazepines in Clinical Practice","author":"Greenblatt DJ","year":"1974"},{"key":"e_1_2_1_10_2","first-page":"1055","article-title":"Disposition of 7\u2010chloro\u20105\u2010(o\u2010chlorophenyl)\u20101,3\/dihydro\u20103\u2010hydroxy\u20102H\u20101,4\u2010benzodiazepin\u20102\u2010one in humans","volume":"21","author":"Knowles JA","year":"1971","journal-title":"Arzneim Forsch"},{"key":"e_1_2_1_11_2","first-page":"497","volume-title":"Antiepileptic Drugs","author":"Mattson RH","year":"1972"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.19.4.332"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.6.513"},{"key":"e_1_2_1_14_2","first-page":"219","article-title":"Preliminary study of parenteral lorazepam in status epilepticus","volume":"75","author":"Waltregny A","year":"1975","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_1_15_2","first-page":"173","article-title":"Preliminary report: parenteral lorazepam in induced epileptic states in man","volume":"76","author":"Waltregny A","year":"1976","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_1_16_2","first-page":"201","volume-title":"The Pharmacological Basis of Therapeutics","author":"Woodbury D","year":"1975"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410060305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410060305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T13:31:08Z","timestamp":1698931868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410060305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,9]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979,9]]}},"alternative-id":["10.1002\/ana.410060305"],"URL":"https:\/\/doi.org\/10.1002\/ana.410060305","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,9]]}}}