{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:49:09Z","timestamp":1792129749556,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":9107,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1979,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tracer techniques and quantitative autoradiographic and tissue counting models for measuremnt of metabolic rates were combined with positron computed tomography (PCT) and (F\u201018)2\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose (FDG) for the measurement of local cerebral metabolic rate for glucose (LCMRGlc) in humans. A three\u2010compartment model, which incorporates hydrolysis of FDG\u20106\u2010PO\n                    <jats:sub>4<\/jats:sub>\n                    to FDG, was developed for the measure of kinetic constants and calculation of LCMRGlc. Our model is an extension of that developed by Sokoloff et al. Although small, hydrolysis of FDG\u20106\u2010PO\n                    <jats:sub>4<\/jats:sub>\n                    was found to be significant. A PCT system, the ECAT, was used to determine the rate constants, lumped constant, and stability of the model in human beings. The data indicate that cerebral FDG\u20106\u2010PO\n                    <jats:sub>4<\/jats:sub>\n                    in humans increases for about 90 minutes, plateaus, and then slowly decreases. After 10 minutes, cerebral blood FDG activity levels were found to be a minor fraction of tissue activity. Precursor pool turnover rate, distribution volumes, and red blood cell\u2010plasma concentration ratios were determined. Reproducibility (precision) of LCMRGlc measurements (\u223c2 cm\n                    <jats:sup>2<\/jats:sup>\n                    regions) was \u00b1 5.5% over a 5\u2010hour period. The replacement of arterial blood sampling with venous sampling was validated.\n                  <\/jats:p>","DOI":"10.1002\/ana.410060502","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:57:17Z","timestamp":1104569837000},"page":"371-388","source":"Crossref","is-referenced-by-count":1984,"title":["Tomographic measurement of local cerebral glucose metabolic rate in humans with (F\u201018)2\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose: Validation of method"],"prefix":"10.1002","volume":"6","author":[{"given":"M. E.","family":"Phelps","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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