{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T22:09:22Z","timestamp":1772402962883,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":9107,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1979,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systematic search for Creutzfeldt\u2010Jakob disease (CJD) in France yielded a total of 170 patients dying between 1968 and 1977. The overall annual mortality rate from CJD for France was 0.32 case per million persons, with by far the highest rate (1.33 cases per million) in the most densely populated parts of Paris. A highly significant correlation between population density and the mortality rate of CJD in the Paris urban agglomeration was consistent with the hypothesis of human\u2010to\u2010human disease transmissison, although in the rest of France CJD occurred at equally low rates among rural and urban populations. Temporospatial case clustering was not observed, nor could occupation, surgery, or potential exposure to scrapie be associated with an increased risk of contracting CJD. Six to 9% of cases were familial, analysis of which discouraged the notion of a familial \u201ccommon exposure\u201d in favor of genetic transmission of susceptibility to the virus or of the virus itself. A prospective epidemiological study of newly occurring cases of CJD, especially familial and geographically isolated cases, is being undertaken in the hope of identifying the means by which CJD is naturally acquired.<\/jats:p>","DOI":"10.1002\/ana.410060511","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:57:17Z","timestamp":1104587837000},"page":"438-446","source":"Crossref","is-referenced-by-count":46,"title":["Creutzfeldt\u2010Jakob disease in France: III. Epidemiological study of 170 Patients dying during the decade 1968\u20131977"],"prefix":"10.1002","volume":"6","author":[{"given":"Paul","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francoise","family":"Cathala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Gajdusek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6118.987"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.186.4166.848"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91958-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050213"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410060510"},{"key":"e_1_2_1_7_2","first-page":"213","volume-title":"Slow Transmissible Diseases of the Nervous System","author":"Brown P","year":"1979"},{"key":"e_1_2_1_8_2","first-page":"165","article-title":"Maladie de Creutzfeldt\u2010Jakob familiale. Etude clinique et anatomique de trois cas sur huit r\u00e9partis sur trois g\u00e9n\u00e9rations. Transmission au singe \u00e9cureuil","volume":"134","author":"Buge A","year":"1978","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_9_2","first-page":"2727","article-title":"Une d\u00e9mence infectieuse souvent m\u00e9connue: la maladie de Creutzfeldt et Jakob","volume":"101","author":"Cathala F","year":"1979","journal-title":"Concour Med"},{"key":"e_1_2_1_10_2","first-page":"1968","volume-title":"Les Collections de l'INSEE, s\u00e9rie D. D\u00e9mographic et Emploi. Situation D\u00e9mographique"},{"key":"e_1_2_1_11_2","volume-title":"Les Collections de l'INSEE, tome 28\/29 R. Statistiques et Indicateurs des R\u00e9gions Francaises. 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