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A male sibling experienced a malignant hyperthermic reaction during hand surgery, and although similar reactions had not been observed in other family members, unexplained ventricular dysrhythmias did occur in the proband during surgery. The proband and his mother were subsequently shown to be susceptible to malignant hyperthermia by abnormal in vitro muscle contractures in the presence of halothane or caffeine.<\/jats:p><jats:p>Physicians and dentists caring for patients with central core disease should be aware of its possible association with malignant hyperthermia. Complete evaluation pf patients with central core disease should include in vitro muscle contracture studies for malignant hyperthermia since many of these patients require surgery for musculo\u2010skeletal defects.<\/jats:p>","DOI":"10.1002\/ana.410070105","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:56:00Z","timestamp":1104598560000},"page":"11-17","source":"Crossref","is-referenced-by-count":60,"title":["Central core disease and malignant hyperthermia syndrome"],"prefix":"10.1002","volume":"7","author":[{"given":"John P.","family":"Frank","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadollah","family":"Harati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian J.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles I.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"AuerbachVH Di GeorgeAM MayerBW et al:Rhabdomyolysis and hyperpyrexia in children after administration of succinylcholine in Gordon RA Britt BA Kalow W (eds): International Symposium on Malignant Hyperpyrexia. 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