{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:40:25Z","timestamp":1770018025609,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":9046,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1980,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fifty patients with Tourette syndrome were evaluated; data included family history, clinical characteristics, response to haloperidol, and side effects during haloperidol therapy. Sixteen patients had a family history of Tourette syndrome, and another 16 had a family history of tics. Twenty\u2010four families had more than 2 members with Tourette syndrome or tics. There was no preponderance of families with a Jewish, Eastern European background in this sample. Thirty\u2010four patients had obsessive\u2010compulsive behavior. Among the 50 patients there was a high frequency of sleep disturbance, learning disability, self\u2010destructive behavior, inappropriate sexual activity, and antisocial behavior. Family history was significantly related to the occurrence of sleep distrubance, obsessivecompulsive behavior, haloperidol response, and the frequency of side effects caused by haloperidol. The precise mode of genetic transmission in familial Tourette syndrome remains to be determined.<\/jats:p>","DOI":"10.1002\/ana.410070109","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T16:56:00Z","timestamp":1104598560000},"page":"41-49","source":"Crossref","is-referenced-by-count":182,"title":["Gilles de la tourette syndrome: Clinical and family study of 50 cases"],"prefix":"10.1002","volume":"7","author":[{"given":"Linda E.","family":"Nee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Caine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Polinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roswll","family":"Eldridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Statistical Manual of Mental Disorders","author":"Diagnostic","year":"1978"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.27.2.115"},{"key":"e_1_2_1_4_2","first-page":"171","volume-title":"Diseases Among Ashkenaci Jews","author":"Eldridge R","year":"1979"},{"key":"e_1_2_1_5_2","first-page":"19","article-title":"Etude sur une affection nerveuse caract\u00e9ris\u00e9e par de l'incoordination notrice accompagn\u00e9e &dcar;\u00e9cholalie et de coprolalie","volume":"9","author":"Gilles de la Tourette G","year":"1885","journal-title":"Arch Neurol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410040208"},{"key":"e_1_2_1_7_2","volume-title":"Statistics for Psychologists","author":"Hays WL","year":"1965"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.2307\/2089217"},{"key":"e_1_2_1_9_2","first-page":"385","article-title":"M\u00e9moire sur quelques fonctions involontaires des appareils de la locomotion, de la pr\u00e9hension et de la voix","volume":"8","author":"Itard JMG","year":"1825","journal-title":"Arch Gen Med"},{"key":"e_1_2_1_10_2","volume-title":"Gilles de la Tourette Syndrome","author":"Shapiro AK","year":"1978"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.3.304"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01067479"},{"key":"e_1_2_1_13_2","volume-title":"Psychiatric Diagnosis","author":"Woodruff RA","year":"1974"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410070109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410070109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T20:17:55Z","timestamp":1698956275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410070109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["10.1002\/ana.410070109"],"URL":"https:\/\/doi.org\/10.1002\/ana.410070109","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1]]}}}