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Pathologically, gross abnormalities of the brain resembled those in progressive multifocal leukoencephalopathy (PML), with discrete and confluent plaque\u2010like lesions concentrated in the white matter, particularly along the gray\u2010white junction. Microscopically, pathological changes differed distinctly from those associated with PML; in addition to confluent foci of white matter injury characterized by early demyelination and subsequent necrosis, prominent Cowdry type A eosinophilic intranuclear inclusions were noted in oligodendrocytes, astrocytes, and neurons. By electron microscopy, intranuclear spherical particles consistent in size and appearance with herpesvirus nucleocapsids were found within the lesions. Immunoperoxidase studies detected varicella\u2010zoster virus (VZV) antigens in infected cells, implicating this virus as the responsible agent despite a lapse of many months between the cutaneous herpes zoster and onset of cerebral symptoms in both patients.<\/jats:p>","DOI":"10.1002\/ana.410090308","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:22:50Z","timestamp":1104585770000},"page":"251-266","source":"Crossref","is-referenced-by-count":84,"title":["Multifocal varicella\u2010zoster virus leukoencephalitis temporally remote from herpes zoster"],"prefix":"10.1002","volume":"9","author":[{"given":"Bruce","family":"Horten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.49.572.393"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1542\/peds.59.2.232","article-title":"Acute measles encephalitis in children with immunosuppression","volume":"59","author":"Aicardia J","year":"1977","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197812)42:6<2631::AID-CNCR2820420619>3.0.CO;2-I"},{"key":"e_1_2_1_5_2","first-page":"267","volume-title":"Hodgkin's Disease","author":"Armstrong D","year":"1976"},{"key":"e_1_2_1_6_2","first-page":"145","volume-title":"Handbook of Clinical Neurology","author":"Baringer JR","year":"1978"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197610)38:4<1807::AID-CNCR2820380458>3.0.CO;2-Y"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197311000-00003"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197301000-00003"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(70)80014-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.2.136"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197901000-00002"},{"key":"e_1_2_1_13_2","first-page":"647","volume-title":"Antiviral Agents and Viral Disease of Man","author":"Haynes RE","year":"1979"},{"key":"e_1_2_1_14_2","first-page":"162","volume-title":"Infections in the Abnormal Host","author":"Fauci AS","year":"1980"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/132.4.421"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-6-842"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.25.1.170-174.1979"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-2-235"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490290049004"},{"key":"e_1_2_1_20_2","first-page":"9","article-title":"The nature of herpes zoster. 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