{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:02:08Z","timestamp":1760644928772},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":8590,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rats maintained on a thiamine\u2010free diet for two to seven weeks and control animals were studied by the [<jats:sup>14<\/jats:sup>C]deoxyglucose technique prior to the development of histological lesions. This technique permits measurement of local cerebral glucose utilization (LCGU) in discrete nuclei and tracts. Levels of thiamine in brain and blood were also determined. In the 41 central nervous system (CNS) structures in which it was measured, cerebral glucose utilization decreased with diminishing concentration of cerebral thiamine. Thus, the primary metabolic consequence of thiamine deficiency is a widespread reduction in cerebral glucose utilization. Furthermore, with decreasing cerebral thiamine concentrations, glucose utilization declined more rapidly in many of the structures which in humans develop histological lesions with prolonged thiamine deficiency than in structures less susceptible to the development of lesions. One determinant of the specific distribution of histological lesions occurring in human thiamine deficiency may be the variable rate at which the CNS structures lose their metabolic activity with continuing thiamine deficiency.<\/jats:p>","DOI":"10.1002\/ana.410090404","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:25:16Z","timestamp":1104585916000},"page":"334-339","source":"Crossref","is-referenced-by-count":54,"title":["The effect of thiamine deficiency on local cerebral glucose utilization"],"prefix":"10.1002","volume":"9","author":[{"given":"A. M.","family":"Hakim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M.","family":"Pappius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1","article-title":"Significance of acetylcholine in thiamine deficiency","volume":"1","author":"Barclay LL","year":"1980","journal-title":"Trans Am Soc Neurochem"},{"key":"e_1_2_1_3_2","first-page":"9","article-title":"Some regional pathologic and metabolic consequences in mouse brain of pyrithiamine\u2010induced thiamine deficiency","volume":"2","author":"Collins RC","year":"1970","journal-title":"J Neuropathol Exp Neurol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1959.tb13191.x"},{"key":"e_1_2_1_5_2","first-page":"4","article-title":"The regional distribution of transketolase in the normal and the thiamine\u2010deficient nervous system","volume":"2","author":"Dreyfus PM","year":"1965","journal-title":"J Neuropathol Exp Neurol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/9.4.414"},{"key":"e_1_2_1_7_2","first-page":"0","article-title":"Local cerebral glucose utilization during resolution of embolic experimental ischemia","volume":"2","author":"Fieschi C","year":"1978","journal-title":"Adv Neurol"},{"key":"e_1_2_1_8_2","first-page":"4","article-title":"Decreased metabolism in vivo of glucose into amino acids of the brain of thiamine\u2010deficient rats after treatment with pyrithiamine","volume":"2","author":"Gaitonde MK","year":"1975","journal-title":"J Neurochem"},{"key":"e_1_2_1_9_2","first-page":"8","article-title":"Alternative pathways of glucose metabolism in fetal rat brain","volume":"14","author":"Guerra RM","year":"1967","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_1_10_2","first-page":"7","article-title":"The pentose phosphate pathway in brain during development","volume":"3","author":"Hakim AM","year":"1980","journal-title":"Biol Neonate"},{"key":"e_1_2_1_11_2","first-page":"7","article-title":"Effects of thiamine deficiency on cerebral and visceral protein synthesis","volume":"2","author":"Henderson GI","year":"1978","journal-title":"Biochem Pharmacol"},{"key":"e_1_2_1_12_2","first-page":"4","article-title":"Carbohydrate metabolism in birds; brain localization of lactic acidosis in avitaminosis B and its relation to symptoms","volume":"2","author":"Kinnersley HW","year":"1930","journal-title":"Biochem J"},{"key":"e_1_2_1_13_2","volume-title":"The Rat Brain\u2013A Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem","author":"Koning JFR","year":"1963"},{"key":"e_1_2_1_14_2","first-page":"2","article-title":"Biochemical evidence of nutritional status","volume":"3","author":"Lowry OH","year":"1952","journal-title":"Physiol Rev"},{"key":"e_1_2_1_15_2","first-page":"7","article-title":"Encephalopathy of thiamine deficiency: studies of intracerebral mechanisms","volume":"4","author":"McCandless DW","year":"1968","journal-title":"J Clin Invest"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050302"},{"key":"e_1_2_1_17_2","first-page":"7","article-title":"Regional distribution of thiamine\u2010dependent enzymes in normal and thiamine\u2010deficient brain","volume":"3","author":"Pincus JH","year":"1972","journal-title":"Exp Neurol"},{"key":"e_1_2_1_18_2","first-page":"1","article-title":"B1 deficiency: 14C\u2010glucose, 3H\u2010acetate and NaH14CO3 flux into brain amino acids","volume":"1","author":"Plaitakis A","year":"1980","journal-title":"Trans Am Soc Neurochem"},{"key":"e_1_2_1_19_2","first-page":"1","article-title":"Thiamine content and turnover rates of some rat nervous regions, using labelled thiamine as a tracer","volume":"18","author":"Rindi G","year":"1980","journal-title":"Brain Res"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1978.234.3.C59"},{"key":"e_1_2_1_21_2","first-page":"8","article-title":"The (14C)\u2010deoxyglucose method for the measurement of local cerebral glucose utilization; theory, procedure and normal values in the conscious and anesthetized albino rat","volume":"2","author":"Sokoloff L","year":"1977","journal-title":"J Neurochem"},{"key":"e_1_2_1_22_2","first-page":"1","article-title":"Effect of thiamine deficiency in pregnant and lactating rats on the brain of their offspring","volume":"2","author":"Trostler N","year":"1977","journal-title":"Nutr Metab"},{"key":"e_1_2_1_23_2","volume-title":"The Wernicke\u2010Korsakoff Syndrome","author":"Victor M","year":"1971"},{"key":"e_1_2_1_24_2","first-page":"0","article-title":"A role for thiamine in the regulation of fatty acid and cholesterol biosynthesis in the cultured cells of neural origin","volume":"3","author":"Volpe JJ","year":"1978","journal-title":"J Neurochem"},{"key":"e_1_2_1_25_2","first-page":"7","article-title":"Effects of thiamine deficiency on acetylcholine levels and utilization in vivo in rat brain","volume":"10","author":"Vorhees CV","year":"1977","journal-title":"J Nutr"},{"key":"e_1_2_1_26_2","first-page":"3","article-title":"An improved method for the determination of endogenous thiamine and its phosphate esters in biological material","volume":"2","author":"Waldenlind L","year":"1979","journal-title":"Nutr Metab"},{"key":"e_1_2_1_27_2","volume-title":"Craigie's Neuroanatomy of the Rat","author":"Zeman W","year":"1963"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410090404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410090404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T13:55:08Z","timestamp":1697723708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410090404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,4]]}},"alternative-id":["10.1002\/ana.410090404"],"URL":"https:\/\/doi.org\/10.1002\/ana.410090404","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}