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Both types of abnormal impulse generation were increased by hypocalcemia induced by disodium edetate infusion, hypocapnia produced by hyperventilation, and, to a lesser extent, alkalosis secondary to sodium bicarbonate administration. This hyperexcitability of fibers could be inhibited by hypoventilation with elevation of Pa or by calcium chloride administration. These results may help explain the pathophysiological basis of paroxysmal symptoms in multiple sclerosis and other disorders in which demyelination is a prominent feature.<\/jats:p>","DOI":"10.1002\/ana.410090411","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:25:16Z","timestamp":1104585916000},"page":"378-383","source":"Crossref","is-referenced-by-count":11,"title":["Ectopic impulse generation in demyelinated axons: Effects of PaCO2<\/sub>, pH, and disodium edetate"],"prefix":"10.1002","volume":"9","author":[{"given":"Kim J.","family":"Burchiel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1946.tb49547.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1980.53.5.0674"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(80)90225-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(77)90078-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.33.6.723"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.34.5.551"},{"key":"e_1_2_1_8_2","first-page":"462","article-title":"The ionized, complexed and proteinbound fractions of calcium in plasma","volume":"27","author":"Fanconi A","year":"1958","journal-title":"Q J Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1957.sp005808"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.51.2.221"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90255-9"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(77)90033-1"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)63723-1"},{"key":"e_1_2_1_14_2","article-title":"A study of nerve physiology","volume":"131","author":"Lorente de N\u00f3 R","year":"1947","journal-title":"Studies of the Rockefeller Institute for Medical Research"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.6.617"},{"key":"e_1_2_1_16_2","first-page":"320","article-title":"\u00dcber die Wirkung der Kationen Verschiebung in der Ringerl\u00f6sung auf den peripheren Nerven","volume":"219","author":"Misske B","year":"1930","journal-title":"Biochem Z"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106241"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/98.2.189"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1978.234.5.C162"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410030413"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.2.152"},{"key":"e_1_2_1_22_2","first-page":"542","article-title":"Changes in serum and spinal fluid calcium effected by disodium ethylenediamine tetraacetate","volume":"58","author":"Soffer A","year":"1961","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_23_2","first-page":"93","article-title":"Effects of calcium\u2010free solutions on membrane\u2010potential of myelinated nerve fibers of the Brazilian frog Leptodactylus ocellatus","volume":"14","author":"Stamfli R","year":"1956","journal-title":"Helv Physiol Pharmacol Acta"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.48.6.1095"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.6_Part_2.18"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410090411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410090411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T13:56:10Z","timestamp":1697723770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410090411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,4]]}},"alternative-id":["10.1002\/ana.410090411"],"URL":"https:\/\/doi.org\/10.1002\/ana.410090411","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}