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Positron tomographic scanning is a potent research tool that can demonstrate both regional glycolysis and blood flow. Unfortunately, it is extremely expensive and complex to apply in a clinical setting. With support from the National Institutes of Health, seven extramural centers have been funded to develop positron tomographic capabilities, and they will greatly advance our knowledge of stroke pathophysiology, seizure disorders brain tumors and various degenerative diseases. Nuclear magnetic resonance imaging is a potentially valuable tool since it creates tomographic images representing the distribution of brain water. No tissue ionization is produced, and images comparable to second\u2010generation computerized tomographic scans are already being produced in humans.<\/jats:p>","DOI":"10.1002\/ana.410100302","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:31:07Z","timestamp":1104582667000},"page":"207-213","source":"Crossref","is-referenced-by-count":11,"title":["Neclear medicine in clinical neurology: An update"],"prefix":"10.1002","volume":"10","author":[{"given":"William H.","family":"Oldendorf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"861","article-title":"Physiologic factors in the selection of patients for superficial temporal artery\u2010to\u2010middle cerebral artery anastomosis","volume":"75","author":"Austin G","year":"1974","journal-title":"Surgery"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.14.3.185"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1978.48.6.0946"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/130.3.681"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/neurosurgery\/24.CN_suppl_1.270","article-title":"The clinical picture in occult hydrocephalus","volume":"24","author":"Fisher CM","year":"1976","journal-title":"Clin Neurosurg"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90027-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1979.50.6.0733"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198010000-00001"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/270722a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500080005002"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-51-609-657"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.4.4.658"},{"key":"e_1_2_1_14_2","series-title":"(Contemporary Neurology Series","first-page":"69","volume-title":"Normal Pressure Hydrocephalus","author":"Katzman R"},{"key":"e_1_2_1_15_2","first-page":"653","article-title":"Image separataion radioisotope scanning","volume":"80","author":"De Kuhl","year":"1963","journal-title":"Radilogy"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1148\/83.5.926"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/121.2.405"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080403"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080108"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.36.5.610"},{"key":"e_1_2_1_21_2","volume-title":"Proceedings of the Tenth International Symposium on Cerebral Blood Flow and Metabolism","author":"De Kuhl","year":"1981"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican1078-62"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/242190a0"},{"key":"e_1_2_1_24_2","first-page":"1963","article-title":"Investigation of cerebral blood\u2010flow in hypertension, using radioactive\u2010xenon inhalation and extracranial recording","volume":"1","author":"Mallett BL","journal-title":"Lancet"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1980.0070"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.20.1.124"},{"key":"e_1_2_1_27_2","first-page":"1182","article-title":"The need for new radiopharmaceuticals","volume":"19","author":"Oldendorf WH","year":"1978","journal-title":"J Necl Med"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.15.11.994"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2998(77)80042-1"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.8.6.694"},{"key":"e_1_2_1_31_2","article-title":"Cerebral blood folw and metablism in man past, present and future","volume":"3","author":"Raichle ME","year":"1980","journal-title":"Trends in Neurosci"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500080001001"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.414358"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.44.1.127"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00239907"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/96.4.737"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb10649.x"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1148\/115.1.197"},{"key":"e_1_2_1_39_2","first-page":"947","article-title":"N \u2010Isopropyl (123I) p \u2010iodoamphetamine: singlepass brain uptake and washout; 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