{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T07:40:40Z","timestamp":1698910840442},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":8437,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fourteen patients with spasmodic torticollis and other segmental dystonic syndromes, who were refractory to previous forms of therapy, were selected for treatment with drugs intended to elevate brain \u03b3\u2010aminobutyric acid (GABA) levels. These patients were simultaneously given diazepam, isoniazid, pyridoxine, and large doses of <jats:sc>L<\/jats:sc>\u2010glutamine. Involuntary spasmodic activity improved to varying degrees in 7 patients; in 2 the dyskinesia became worse. Transient alteration of renal or hepatic function occurred in 6 patients and mild euphoria unrelated to neurological improvement in 8. Two patients are still being treated. Deficiency of GABA may be a factor in some patients with these disorders.<\/jats:p>","DOI":"10.1002\/ana.410100309","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:31:07Z","timestamp":1104582667000},"page":"247-250","source":"Crossref","is-referenced-by-count":12,"title":["Effect of <scp>L<\/scp>\u2010glutamine and isoniazid on torticollis and segmental dystonia"],"prefix":"10.1002","volume":"10","author":[{"given":"Juulius","family":"Korein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Kupersmith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Levidow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"535","article-title":"L\u2010Glutamine increases cerebrospinal fluid (CSF) gamma aminobutyric acid (GABA) in a patient with Huntington disease (HD)","volume":"29","author":"Berry Hk JC","year":"1979","journal-title":"Neurology"},{"key":"e_1_2_1_3_2","first-page":"369","volume-title":"The Basal Ganglia","author":"Cooper IS","year":"1976"},{"key":"e_1_2_1_4_2","first-page":"413","volume-title":"GABA in Nervous System Function","author":"Costa E","year":"1976"},{"key":"e_1_2_1_5_2","unstructured":"Eldridge R Fahn S (eds):"},{"key":"e_1_2_1_5_3","first-page":"1","volume":"14","year":"1976","journal-title":"Adv Neurol"},{"key":"e_1_2_1_6_2","first-page":"417","article-title":"General discussion of drug therapy in dystonia","volume":"14","author":"Eldridge R","year":"1976","journal-title":"Adv Neurol"},{"key":"e_1_2_1_7_2","first-page":"31","article-title":"Symposium on Therapeutic Controversies in Movement Disorders, 1979","volume":"104","author":"Fahn S","year":"1979","journal-title":"Trans Am Neurol Assoc"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","unstructured":"Fonnum F (ed):Amino acids as chemical transmitters. 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