{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:28:42Z","timestamp":1791088122513,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":8407,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1981,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of pharmacological alteration of the monoamine systems were investigated in a canine model of narcolepsy. Cataplexy was quantified in eight severely affected dogs by means of the food\u2010elicited cataplexy test. The specific norepinephrine (NE) uptake blocker nisoxetine, and (to a much lesser extent) the specific serotonin (5\u2010HT) uptake blocker fluoxetine, significantly suppressed cataplexy, as did the tricy'lic antidepressants protriptyline, amitriptyline, and chlorimipramine. Thus, experimental cataplexy is suppressed more by inhibition of the uptake of NE than of 5\u2010HT. Methylphenidate, the \u03b1\u2010adrenoreceptor blocker clonidine, and the dopamine receptor blocker pimozide also suppressed cataplexy in dogs. The \u03b2\u2010adrenergic blocker propranolol, the fatty acid \u03b3\u2010hydroxybutyrate, and the monoamine oxidase inhibitors clorgyline and pargyline had little or no effect. With one exception (pimozide). all the drugs that suppressed cataplexy are known to be potent suppressors of REM sleep. The suppression of cataplexy induced by nisoxetine or protriptyline was reversed by the anticholinesterase physostigmine, further supporting a postulated aminergic\u2010cholinergic interaction in the mechanisms for cataplexy.<\/jats:p>","DOI":"10.1002\/ana.410100409","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:18:47Z","timestamp":1104585527000},"page":"369-376","source":"Crossref","is-referenced-by-count":40,"title":["Monoaminergic mechanisms and experimental cataplexy"],"prefix":"10.1002","volume":"10","author":[{"given":"Arthur S.","family":"Foutz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John B.","family":"Delashaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Guilleminault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Dement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(76)90298-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197816040-00001"},{"key":"e_1_2_1_4_2","first-page":"23","article-title":"Effects of nocturnal \u03b3\u2010hydroxybutyrate on sleep\/waking patterns in narcolepsycataplexy","volume":"7","author":"Broughton R","year":"1980","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(79)90218-8"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00572267"},{"key":"e_1_2_1_7_2","first-page":"114","article-title":"The disposition of propranolol. 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