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Such a mechanism may explain the generalized periodic sharp waves that characterize the electroencephalogram of many patients with Creutzfeldt\u2010Jakob disease. In Creutzfeldt\u2010Jakob disease, fusions of neuronal processes, particularly dendrites, may lead to abnormal electrotonic coupling between cells, providing the basis for powerful excitatory interaction whereby large neuronal aggregates burst in near synchrony. Cortical synchronous discharges would give rise to sharp waves in the electroencephalogram, whereas similar discharges in brainstem, spinal cord, or elsewhere could lead to myoclonic jerks.<\/jats:p>","DOI":"10.1002\/ana.410100502","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:19:59Z","timestamp":1104585599000},"page":"405-410","source":"Crossref","is-referenced-by-count":64,"title":["Virus\u2010induced electrotonic coupling: Hypothesis on the mechanism of periodic EEG discharges in Creutzfeldt\u2010Jakob disease"],"prefix":"10.1002","volume":"10","author":[{"given":"Roger D.","family":"Traub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Pedley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.7444438","article-title":"Epileptiform burst afterhyperpolarization: calcium\u2010dependent potassium potential in hippocampal CA1 pyramidal cells","volume":"210","author":"Alger BE","year":"1980","journal-title":"Science"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.6.611"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-129-33377"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/98.4.595"},{"key":"e_1_2_1_6_2","first-page":"357","volume-title":"Handbook of Physiology, Section 1: The Nervous System, Vol 1, Part 1, Cellular Biology of Neurons","author":"Bennett MVL","year":"1977"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91958-4"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(78)90161-X"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0370-4475(80)80021-9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490110062006"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198011133032008"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(73)90241-1"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1980.00500520041005"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(73)90093-X"},{"key":"e_1_2_1_15_2","unstructured":"CourtL CathalaF RohmerF et al: Etude de l'\u00e9volution clinique et mise en \u00e9vidence de singes enc\u00e9phalographiques par \u00e9lectrodes implant\u00e9es \u00e0 demeure chez le chimpanz\u00e9 d'une transmission exp\u00e9rimental d'un cas de maladie de Creutzfeldt\u2010Jakob. 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