{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:59:07Z","timestamp":1770501547921,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":8315,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ammonia metabolism in Reye syndrome was studied by quantitative analysis of the time course of hyperammonemia and the urinary excretion of ammonia, urea, and total nitrogen. These measures were then utilized to assess the effect of citrulline administration in 8 patients compared to results in 22 patients managed without citrulline. Two indices of the severity and duration of hyperammonemia correlated strongly with mortality: the half\u2010time for decline of hyperammonemia and the area under the hyperammonemia curve (an index of the total burden of ammonia presented to the brain). These results suggest that the total amount of ammonia delivered to brain may be important to the pathogenesis of encephalopathy. Citrulline\u2010treated patients had more severe disease at admission and greater abnormalities in indices of nitrogen and ammonia metabolism, though the latter did not reach significance. The urine ammonia\/urea nitrogen excretion ratio, an index of the efficiency of ammonia conversion to urea, normalized more rapidly in the citrulline\u2010treated group, evidence that citrulline may have improved urea cycle function. Overall mortality did not differ in the two groups. The deaths of 2 citrulline\u2010treated patients in this small group were attributable to factors unrelated to treatment, however, so the possible effect of citrulline on mortality was not definitively tested. No indication was found that citrulline was harmful, nor that it increased ammonia levels.<\/jats:p>","DOI":"10.1002\/ana.410110110","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:28:02Z","timestamp":1104586082000},"page":"53-58","source":"Crossref","is-referenced-by-count":8,"title":["Ammonia metabolism in Reye syndrome and the effect of citrulline"],"prefix":"10.1002","volume":"11","author":[{"given":"G. Robert","family":"Delong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Glick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80416-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197604152941602"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197301042880101"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1542\/peds.60.5.708","article-title":"Reye's syndrome: Clinical progression and evaluation of therapy","volume":"60","author":"Corey L","year":"1977","journal-title":"Pediatrics"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197406272902616"},{"key":"e_1_2_1_7_2","first-page":"329","volume-title":"Reye's Syndrome","author":"DeLong GR","year":"1975"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80085-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1542\/peds.60.4.557","article-title":"Potential hazard of therapy for Reye's syndrome with urea cycle intermediates","volume":"60","author":"Glasgow AM","year":"1977","journal-title":"Pediatrics"},{"key":"e_1_2_1_10_2","first-page":"159","article-title":"Exchange transfusion to remove ammonia","volume":"129","author":"Glasgow AM","year":"1975","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_11_2","first-page":"401","volume-title":"Reye's Syndrome","author":"Good TA","year":"1975"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410030305"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80717-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517109095710"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365517109095711"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(73)90024-1"},{"key":"e_1_2_1_17_2","first-page":"36","article-title":"Clinical staging in Reye's syndrome","volume":"128","author":"Lovejoy PH","year":"1974","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197112092852402"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197811000-00003"},{"key":"e_1_2_1_20_2","first-page":"295","volume-title":"Reye's Syndrome","author":"Samaha FJ","year":"1975"},{"key":"e_1_2_1_21_2","first-page":"155","volume-title":"Reye's Syndrome II","author":"Schubert WK","year":"1979"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1542\/peds.56.6.999","article-title":"Studies on the pathophysiology of encephalopathy in Reye's syndrome: hyperammonemia in Reye's syndrome","volume":"86","author":"Shannon DC","year":"1975","journal-title":"Pediatrics"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1542\/peds.66.2.198","article-title":"Monitoring and management of increased intracranial pressure in Reye's syndrome: results in 29 children","volume":"66","author":"Shaywitz BA","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197509110-00005"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197604152941601"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410110110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410110110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T17:27:54Z","timestamp":1698946074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410110110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1002\/ana.410110110"],"URL":"https:\/\/doi.org\/10.1002\/ana.410110110","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}