{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T23:27:03Z","timestamp":1775863623442,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":8225,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1982,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the past five years, 15 patients with subacute sclerosing panencephalitis (SSPE) were treated with inosiplex. Using a disability index specifically designed for the disease, this study monitored the course of SSPE in each patient before and during inosiplex therapy. Posttreatment follow\u2010up ranged from 2 to 144 months. Inosiplex had an apparently beneficial effect on morbidity and mortality in 10 of the 15 patients tested. Eight improved immediately after treatment, 2 had a delayed improvement, and 1 patient stabilized. Four patients followed a typical course for SSPE and died a mean of 9 months after onset. Treatment was not associated with adverse reactions. Due to its low risk\u2010benefit ratio, inosiplex is recommended for continuous use in SSPE even after extended remissions.<\/jats:p>","DOI":"10.1002\/ana.410110407","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:30:35Z","timestamp":1104586235000},"page":"359-364","source":"Crossref","is-referenced-by-count":96,"title":["Long\u2010term follow\u2010up of patients with subacute sclerosing panencephalitis treated with inosiplex"],"prefix":"10.1002","volume":"11","author":[{"given":"Paul R.","family":"Dyken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Swift","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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