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An increased ratio of muscle sodium permeability to potassium permeability reduces the ionic diffusion potential, while the resting membrane potential is sustained by an increase of Na\u2010K pump electrogenesis. The result is that potassium entry (the sum of active and passive influx) exceeds potassium efflux; this causes a large shift of extracellular potassium into muscle until the Na\u2010K pump turns off, leading to depolarization and paralysis. The primary defect in familial hypokalemic periodic paralysis, as in the example of barium poisoning, may be a marked reduction of muscle permeability to potassium.<\/jats:p>","DOI":"10.1002\/ana.410110602","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:34:29Z","timestamp":1104586469000},"page":"547-552","source":"Crossref","is-referenced-by-count":92,"title":["Periodic paralysis and the sodium\u2010potassium pump"],"prefix":"10.1002","volume":"11","author":[{"given":"Robert B.","family":"Layzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"47","article-title":"Observations on a case of familial periodic paralysis","volume":"3","author":"Aitken RS","year":"1937","journal-title":"Clin Sci"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6267696"},{"key":"e_1_2_1_4_2","first-page":"296","article-title":"Pa Ping, or Kiating paralysis","volume":"51","author":"Allen AS","year":"1943","journal-title":"Chin Med J"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)91125-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107499"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp013026"},{"key":"e_1_2_1_8_2","first-page":"715","volume-title":"Pathogenesis of Human Muscular Dystrophies","author":"Bryant SH","year":"1977"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1974.00490380058007"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011958"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp011703"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.63700100023014"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-81-3-332"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)90282-X"},{"key":"e_1_2_1_15_2","first-page":"685","article-title":"Effect of thyroid hormones on biochemical processes","volume":"31","author":"Edelman IS","year":"1979","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.19.9.851"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(65)90138-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1152\/ajplegacy.1941.135.1.230","article-title":"Certain effects of desoxycorticosterone. 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