{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:26:05Z","timestamp":1786976765722,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":8164,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1982,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A patient had the rare combination of central neurogenic hyperventilation (Pa\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-inf-1.gif\" xlink:title=\"urn:x-wiley:03645134:media:ANA410110612:tex2gif-inf-1\"\/>\n                    of 9 torr) and a normal level of consciousness for eight days. Morphine attenuated but never corrected the hyperventilation. Experimental effects of hypocapnia, which decreases both cerebral blood flow and metabolism in humans, are at odds with the normal mentation initially seen in this patient despite her marked and persistent hypocapnia. Death occurred after progressive brainstem dysfunction. Pathological study showed a well\u2010differentiated astrocytoma involving primarily the medulla and pons, with scattered tumor foci throughout the entire neuraxis. Possible mechanisms for central neurogenic hyperventilation are discussed briefly in relation to the pathological findings and the observed response to morphine.\n                  <\/jats:p>","DOI":"10.1002\/ana.410110612","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T08:34:29Z","timestamp":1104568469000},"page":"625-628","source":"Crossref","is-referenced-by-count":33,"title":["Central neurogenic hyperventilation in an awake patient with brainstem astrocytoma"],"prefix":"10.1002","volume":"11","author":[{"given":"Moses","family":"Rodriguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe L.","family":"Baele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Michael","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196509000-00007"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90863-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90965-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707142970206"},{"key":"e_1_2_1_6_2","first-page":"448","article-title":"A comparative study in the cat of the respiratory effects of morphine injected intravenously and into the cerebrospinal fluid","volume":"163","author":"Fl\u00f3rez J","year":"1968","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90699-0"},{"key":"e_1_2_1_8_2","first-page":"636","article-title":"Hyperventilation primitive par gliome bulbo\u2010protub\u00e9rantiel","volume":"121","author":"Goulon M","year":"1969","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/245447a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.28.4.317"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-196911000-00017"},{"key":"e_1_2_1_12_2","first-page":"30","volume-title":"The Diagnosis of Stupor and Coma","author":"Plum F","year":"1980"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1959.02340170001001"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410110612","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410110612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T07:45:23Z","timestamp":1697701523000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410110612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1982,6]]}},"alternative-id":["10.1002\/ana.410110612"],"URL":"https:\/\/doi.org\/10.1002\/ana.410110612","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,6]]}}}