{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:12:39Z","timestamp":1758478359477},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":8134,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1982,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Concentrations of 3\u2010methoxy\u20104\u2010hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5\u2010hydroxyindoleacetic acid (5\u2010HIAA) were measured in human lumbar crerospinal fluid following storage at room temperature and 4\u00b0C for intervals up to 72 hours. These monoamine metabolites were quantitated using a high\u2010performance liquid chromatographic\u2014electrochemical detector technique. No significant difference could be detected in any of the three metabolites stored at room temperature for up to 48 hours. Additionof ascorbic acid to CSF had no measurable effect on the levels of HVA and 5\u2010HIAA. Repeated thawing and freezing produced no detectable change in metabolite levels.<\/jats:p><jats:p>The results indicate that these monoamine metabolites are stable at room temperature for up to 48 hours after lumbar puncture and that the addition of an antioxdant, such as ascorbic acid, is not necessary. The data also demonstrate that immediate refrigeration or freezing of samples is not required for maintenance of metabolite levels.<\/jats:p>","DOI":"10.1002\/ana.410120109","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:36:44Z","timestamp":1104583004000},"page":"48-51","source":"Crossref","is-referenced-by-count":14,"title":["Stability of monoamine metabolites in human cerebrospinal fluid"],"prefix":"10.1002","volume":"12","author":[{"given":"Philip J.","family":"Langlais","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward D.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"McEntee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb06003.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1136\/jnnp.40.12.1136","article-title":"CSF studies on the relationship between dopamine and 5\u2010hydroxytrypatamine in parkinsonism and other movement disorders","volume":"40","author":"Davidson DLW","year":"1972","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(71)90305-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/clinchem\/26.6.786","article-title":"Rapid liquiedchromatographic measurement of 3\u2010methoxy\u20104\u2010hydroxyphenylglycol and other monoamine metabolites in human cerebrospinal fluid","volume":"26","author":"Langlais PJ","year":"1980","journal-title":"Clin Chem"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.8.1157"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.715450"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000115048"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4076.897"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.135.8.907"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(80)90099-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.10.887"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410120109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410120109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T04:36:44Z","timestamp":1698899804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410120109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,7]]}},"alternative-id":["10.1002\/ana.410120109"],"URL":"https:\/\/doi.org\/10.1002\/ana.410120109","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,7]]}}}