{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:25:06Z","timestamp":1790900706749,"version":"4.1.0"},"reference-count":91,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":8103,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1982,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vaccines prepared from whole, killed organisms (pertussis and possible influenza) may cause neurological allergic reactions producing encephalopathy. These reactions are characterized by acute, monophasic demyelinative processes and occur with no greater frequency than 1 per 100,000 vaccine recipients; onset is within 4 days of immunization, and recovery is usually complete. No evidence suggests that these vaccines produce an insidious, progressive encephalopathy. Only with the swine influenza program of 1976 has Guillain\u2010Barr\u00e9 syndrome appeared to follow immunization.<\/jats:p><jats:p>Vaccines prepared from live\u2010attenuated viruses (measles, mumps, rubella, and trivalent oral poliovirus) can cause symptomatic viral infection of the nervous system, including measles encephalitis, which occurs in 1 of 1,000,000 vaccine recipients; rubella neuritis, in less than 1 of 10,000 recipients; and paralytic poliomyelitis, in 1 of 3,000,000 vaccine recipients or their close contacts. A cause\u2010and\u2010effect relationship between immunization and brachial plexus neuritis, acute transverse myelitis, and cranial neuropathies has been suggested by never proved.<\/jats:p>","DOI":"10.1002\/ana.410120202","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:34:37Z","timestamp":1104586477000},"page":"119-128","source":"Crossref","is-referenced-by-count":110,"title":["Neurological complications of immunization"],"prefix":"10.1002","volume":"12","author":[{"given":"Gerald M.","family":"Fenichel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410020106"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(75)90109-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03260060037015"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1963.00460080021002"},{"key":"e_1_2_1_6_2","first-page":"188","article-title":"Neurological complications following antirabies vaccination","volume":"151","author":"Appelbaum E","year":"1953","journal-title":"JAMA"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090703"},{"key":"e_1_2_1_8_2","first-page":"565","article-title":"Criteria for diagnosis of Gullain\u2010Barr\u00e9 syndrome","volume":"3","author":"Asbury AK","year":"1978","journal-title":"Ann Neurol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.239.21.2275"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6054.166-b"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1977.04450090171018"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196910162811604"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1931.02730040009002"},{"key":"e_1_2_1_14_2","first-page":"510","article-title":"Centers for Disease Control: Poliomyelitis prevention","volume":"28","year":"1979","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_1_15_2","first-page":"87","article-title":"Centers for Disease Control: Mumps vaccine","volume":"29","year":"1980","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_1_16_2","first-page":"37","article-title":"Centers for Disease Control: Rubella prevention","volume":"30","year":"1981","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(80)90019-7"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500160072021"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.215.3.486"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.224.9.1299b"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1542\/peds.68.5.650","article-title":"Nature and rates of adverse reactions with DPT and DT immunizations in infants and children","volume":"68","author":"Cody CL","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.2.208"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090719"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197708042970503"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1977.00780280041004"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090709"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410030523"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1977.tb114544.x"},{"key":"e_1_2_1_29_2","first-page":"82","article-title":"Isolated hypoglossal nerve paralysis following influenza vaccination","volume":"130","author":"Felix JK","year":"1976","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.2.277"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1091519"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91046-7"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197809282991315"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80497-9"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00312965"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.216.13.2137"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91420-9"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6043.1037"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198106253042601"},{"key":"e_1_2_1_40_2","first-page":"972","article-title":"Encephalitis after administration of live measles vaccine","volume":"112","author":"Jagdis F","year":"1975","journal-title":"Can Med Assoc J"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1971.02100160052004"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(78)90304-5"},{"key":"e_1_2_1_43_2","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1001\/jama.1970.03180130021004","article-title":"Two syndromes following rubella immunization: clinical observations and epidemiological studies","volume":"214","author":"Kilroy AW","year":"1970","journal-title":"JAMA"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.40.4.560"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80755-5"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.49.1.46"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.223.13.1459"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490220060009"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992287301200912"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.2.134"},{"key":"e_1_2_1_51_2","first-page":"128","article-title":"Control of measles and rubella through the use of attenuated vaccines","volume":"70","author":"Meyer HM","year":"1978","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5401.75"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6276.1595"},{"key":"e_1_2_1_54_2","first-page":"1","article-title":"Neurological sequelae of prophylactic inoculation","volume":"23","author":"Miller HG","year":"1954","journal-title":"Q J Med"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.59.4.505"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992287901800105"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197913050-00005"},{"key":"e_1_2_1_58_2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1542\/peds.41.5.997","article-title":"Reported neurological disorders following live measles vaccine","volume":"41","author":"Nader PR","year":"1968","journal-title":"Pediatrics"},{"key":"e_1_2_1_59_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.217.2.212"},{"key":"e_1_2_1_60_2","first-page":"151","article-title":"Transverse myelopathy in childhood","volume":"85","author":"Paine RS","year":"1953","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)90003-1"},{"key":"e_1_2_1_62_2","first-page":"545","article-title":"Reversible blindness in optic neuritis associated with influenza vaccination","volume":"11","author":"Perry HD","year":"1979","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_1_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(78)90232-0"},{"key":"e_1_2_1_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112896"},{"key":"e_1_2_1_65_2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1542\/peds.48.6.923","article-title":"Vaccine\u2010associated poliomyelitis in a child with thymic abnormality","volume":"48","author":"Riker JB","year":"1971","journal-title":"Pediatrics"},{"key":"e_1_2_1_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410040110"},{"key":"e_1_2_1_67_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197011262832208"},{"key":"e_1_2_1_68_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-78-5-643"},{"key":"e_1_2_1_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1980.tb07099.x"},{"key":"e_1_2_1_70_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1980.00500580060009"},{"key":"e_1_2_1_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.2.228"},{"key":"e_1_2_1_72_2","first-page":"243","article-title":"Eradication of poliomyelitis in the United States: II","volume":"2","author":"Salk D","year":"1980","journal-title":"Experience with killed poliovirus vaccine. Rev Infect Dis"},{"key":"e_1_2_1_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.2.258"},{"key":"e_1_2_1_74_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1974.02110240070008"},{"key":"e_1_2_1_75_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00313490"},{"key":"e_1_2_1_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112795"},{"key":"e_1_2_1_77_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090707"},{"key":"e_1_2_1_78_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.7.725"},{"key":"e_1_2_1_79_2","first-page":"546","article-title":"Vaccine\u2010derived poliomyelitis","volume":"119","author":"Shaw EB","year":"1970","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_80_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.213.13.2272c"},{"key":"e_1_2_1_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/87.1.1"},{"key":"e_1_2_1_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80498-0"},{"key":"e_1_2_1_83_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.33.2.150"},{"key":"e_1_2_1_84_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-2-203"},{"key":"e_1_2_1_85_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.199.2.129"},{"key":"e_1_2_1_86_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490140013004"},{"key":"e_1_2_1_87_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1956.00250240155017"},{"key":"e_1_2_1_88_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500200078021"},{"key":"e_1_2_1_89_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5777.755"},{"key":"e_1_2_1_90_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6074.1450"},{"key":"e_1_2_1_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(64)80160-8"},{"key":"e_1_2_1_92_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490140086012"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410120202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410120202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T05:13:07Z","timestamp":1698901987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410120202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8]]},"references-count":91,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,8]]}},"alternative-id":["10.1002\/ana.410120202"],"URL":"https:\/\/doi.org\/10.1002\/ana.410120202","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8]]}}}