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The folate\u2010deficient patients were classified according to whether they exhibited a neuropsychiatric syndrome, consisting of organic mental changes, polyneuropathy, and depression, which responded to folate administration. CSF 5\u2010hydroxyindoleacetic acid was low in the vitamin B<jats:sub>12<\/jats:sub>\u2010deficient patients and in those folate\u2010deficient patients whose neuropsychiatric signs were responsive to folate administration, but was normal in the folate\u2010deficient patients whose symptoms were not related to folate deficiency. CSF 5\u2010hydroxyindoleacetic acid returned to normal with folate treatment in the patients exhibiting folate\u2010responsive neuropsychiatric signs. The data indicate a close association between folate\u2010responsive neuropsychiatric symptoms and change in 5\u2010hydroxytryptamine metabolism in the central nervous system.<\/jats:p>","DOI":"10.1002\/ana.410120512","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:38:36Z","timestamp":1104586716000},"page":"479-484","source":"Crossref","is-referenced-by-count":82,"title":["Effect of folic acid and vitamin B<sub>12<\/sub> deficiencies on 5\u2010hydroxyindoleacetic acid in human cerebrspinal fluid"],"prefix":"10.1002","volume":"12","author":[{"given":"M. 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