{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T18:40:16Z","timestamp":1697913616211},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7950,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical significance of serum aspartate aminotransferase (GOT) isozymes was studied in 18 patients with polymyositis. Abnormally high levels of mitochondrial GOT (mGOT) (6.2 \u00b1 1.2 IU\/L, mean \u00b1 SEM; normal, &lt;2.0 IU\/L) and cytosol GOT (sGOT) (95 \u00b1 21.6 IU\/L; normal, &lt;25 IU\/L) were observed in sera. In polymyositic muscles, the sGOT level was significantly decreased but mGOT was not. The levels of serum sGOT and mGOT and the ratio of mGOT\/tGOT before corticosteroid therapy correlated well with the severity of muscle weakness. Serial determination of CPK, sGOT, and mGOT during corticosteroid therapy revealed that mGOT most rapidly returned to normal. Exercise did not increase serum mGOT in polymyositis.<\/jats:p>","DOI":"10.1002\/ana.410130122","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:40:02Z","timestamp":1104586802000},"page":"100-103","source":"Crossref","is-referenced-by-count":4,"title":["Serum mitochondrial aspartate aminotransferase in patients with polymyositis"],"prefix":"10.1002","volume":"13","author":[{"given":"Saburo","family":"Ogasahara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Yorifuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Wada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Hazama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichiro","family":"Tarui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(61)90953-2"},{"key":"e_1_2_1_3_2","first-page":"51","volume-title":"Handbook of Clinical Neurology","author":"Hudgson P","year":"1979"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000459582"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.40.11.1251"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103055"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry OH","year":"1951","journal-title":"J Biol Chem"},{"key":"e_1_2_1_8_2","first-page":"231","article-title":"Mitochondrial fraction of serum glutamic\u2010oxaloacetic transaminase in Duchenne muscular dystrophy","volume":"83","author":"Matsuda I","year":"1973","journal-title":"Clin Chim Acta"},{"key":"e_1_2_1_9_2","first-page":"417","volume-title":"Disorders of Voluntary Muscle","author":"Pennington RJT","year":"1981"},{"key":"e_1_2_1_10_2","first-page":"696","article-title":"An improved procedure for serum CPK determination","volume":"69","author":"Rosalki SB","year":"1967","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(67)90067-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490290083012"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60346-5"},{"key":"e_1_2_1_14_2","volume-title":"Polymyositis","author":"Walton JN","year":"1958"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410130122","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410130122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T12:07:23Z","timestamp":1697803643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410130122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1002\/ana.410130122"],"URL":"https:\/\/doi.org\/10.1002\/ana.410130122","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}