{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:28:55Z","timestamp":1788438535277,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7919,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The analgesic meperidine has been reported to produce signs of central nervous system excitation in human beings. To determine the relationship between signs and symptoms of central nervous system excitation and plasma levels of meperidine and normeperidine, we studied 67 patients receiving meperidine for the relief of postoperative or chronic pain. In 48 patients, excitatory effects ranging from mild nervousness to tremors, twitches, multifocal myoclonus, and seizures were directly correlated with accumulation of normeperidine in plasma. Evidence of compromised renal function occurred in only 14 of the 48 symptomatic patients, suggesting that renal dysfunction may contribute to but is not the sole factor in the accumulation of normeperidine or its relation to adverse neurological signs. In a second study we surveyed mood alterations in 47 patients receiving meperidine and 29 receiving other narcotic analgesics for postoperative pain. The repeated administration of meperidine was associated with adverse alterations in various elements of mood (e.g., apprehension, sadness, restlessness).<\/jats:p>","DOI":"10.1002\/ana.410130213","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:40:05Z","timestamp":1104586805000},"page":"180-185","source":"Crossref","is-referenced-by-count":329,"title":["Central nervous system excitatory effects of meperidine in cancer patients"],"prefix":"10.1002","volume":"13","author":[{"given":"Robert F.","family":"Kaiko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Foley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Y.","family":"Grabinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Heidrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada G.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Inturrisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus M.","family":"Reidenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"89","article-title":"Cortical effects of Demerol","volume":"76","author":"Andrews HL","year":"1942","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_3_2","first-page":"289","article-title":"The physiological disposition and fate of meperidine (Demerol) in man and a method for its estimation in plasma","volume":"114","author":"Burns JJ","year":"1955","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.504986"},{"key":"e_1_2_1_5_2","first-page":"2460","article-title":"The toxicity of meperidine in the monkey as influenced by its rate of absorption","volume":"6","author":"Deneau GA","year":"1961","journal-title":"Bull Drug Addict Narcot Appendix"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(74)90023-6"},{"key":"e_1_2_1_7_2","first-page":"44","volume-title":"Narcotics and Narcotic Antagonists","author":"Foldes FF","year":"1964"},{"key":"e_1_2_1_8_2","first-page":"538","article-title":"Antagonism of the convulsant effects of heroin, d\u2010propoxyphene, meperidine, normeperidine and thebaine by naloxone in mice","volume":"192","author":"Gilbert PE","year":"1975","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_9_2","first-page":"64","article-title":"Studies of the addiction liability of \u201cDem\u2010erol\u201d (D\u2010140)","volume":"75","author":"Himmelsbach CK","year":"1942","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_10_2","first-page":"5","article-title":"Further studies of the addiction liability of Demerol","volume":"79","author":"Himmelsbach CK","year":"1943","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt196012163"},{"key":"e_1_2_1_12_2","first-page":"515","volume-title":"The Pharmacologic Basis of Therapeutics","author":"Jaffe JH","year":"1980"},{"key":"e_1_2_1_13_2","first-page":"108","volume-title":"Proceedings of the Committee on Problems of Drug Dependence","author":"Jasinski DR","year":"1973"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198106183042501"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1974164667"},{"key":"e_1_2_1_16_2","first-page":"381","article-title":"The separate and combined respiratory effects of chlorpromazine and meperidine in normal men controlled at 46 mm Hg alveolar pCO2","volume":"131","author":"Lambertsen CJ","year":"1961","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1955.02950290026009"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1946.tb00022.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/47.12.1269"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt197517121"},{"key":"e_1_2_1_21_2","first-page":"191","article-title":"The effect of N\u2010demethylation on certain pharmacologic actions of morphine, codeine, and meperidine in the mouse","volume":"112","author":"Miller JW","year":"1954","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1978.tb01591.x"},{"key":"e_1_2_1_23_2","first-page":"377","article-title":"The metabolism of N\u2010C14H3 labeled meperidine","volume":"104","author":"Plotnikoff NP","year":"1952","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_24_2","first-page":"414","article-title":"Biotransformation products of meperidine excreted in the urine of man","volume":"117","author":"Plotnikoff NP","year":"1956","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_25_2","first-page":"6","volume-title":"Survey of analgesic drug prescribing patterns","author":"Seitner PG","year":"1975"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5197.507"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1981.tb05691.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92606-X"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)85713-1"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-6-738"},{"key":"e_1_2_1_31_2","unstructured":"UmansJG InturrisiCE: Antinociceptive activity and toxicity of meperidine and normeperidine in mice.J Pharmacol Exp Ther(in press)"},{"key":"e_1_2_1_32_2","first-page":"477","article-title":"The absorption, distribution and excretion of isonipecaine (Demerol)","volume":"96","author":"Way EL","year":"1949","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410130213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410130213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T16:39:29Z","timestamp":1697733569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410130213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,2]]}},"alternative-id":["10.1002\/ana.410130213"],"URL":"https:\/\/doi.org\/10.1002\/ana.410130213","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,2]]}}}