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Spinal fluid examinations for homovanillic acid, 3,4\u2010dihydroxyphenylacetic acid, 3\u2010methoxy\u20104\u2010hydroxyphenylethylene glycol, and 5\u2010hydroxyindoleacetic acid were carried out before and after administration of probenecid on the 20 patients and 40 controls. Probenecid\u2010corrected accumulation of the dopamine metabolites was significantly increased in each of the patient groups, suggesting an association between pathological sleepiness and elevated dopamine turnover in the central nervous system.<\/jats:p>","DOI":"10.1002\/ana.410130306","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:40:21Z","timestamp":1104586821000},"page":"258-263","source":"Crossref","is-referenced-by-count":56,"title":["Cerebrospinal fluid monoamine metabolites in narcolepsy and hypersomnia"],"prefix":"10.1002","volume":"13","author":[{"given":"Kym F.","family":"Faull","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Guilleminault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip A.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack D.","family":"Barchas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/sleep\/3.3-4.247","article-title":"Cerebrospinal fluid homovanillic acid and 5\u2010hydroxyindoleacetic acid in hypersomnia with periodic apneas or idiopathic hypersomnia: preliminary results","volume":"3","author":"Baruzzi A","year":"1980","journal-title":"Sleep"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.137.2.174"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(77)90456-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)81637-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200050408"},{"key":"e_1_2_1_7_2","first-page":"379","article-title":"Clinical application of the probenecid test for measurement of monoamine turnover in the CNS","volume":"16","author":"Faull KF","year":"1981","journal-title":"Biol Psychiatry"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.130.1.73"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(76)90206-X"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-147850-6.50019-2"},{"key":"e_1_2_1_11_2","first-page":"933","volume-title":"Psychopharmacology: A Generation of Progress","author":"Kopin IJ","year":"1978"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000114792"},{"key":"e_1_2_1_13_2","unstructured":"MontplaisirJ RemillardG de ChamplainJ et al:Low dopamine and indoleacetic acid concentrations in the CSF of human hypersomniacs. 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