{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:21:48Z","timestamp":1768083708857,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7860,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1983,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rhesus monkeys were subjected to one, two, or four periods of thiamine deficiency to determine how the number of deprivation episodes affects the development and progression of neurological and neuropathological changes. Recrurent thiamine deprivation produced all major neurological signs and most of the anatomical lesions found in Wernicke\u2010Korsakoff syndrome. Neither the number and gravity of neurological symptoms nor the extent or location of lesions was related to the number of deprivation periods in a simple way. Thus, some structures, such as the inferior colliculus and medial vestibular nuclei, were affected after only one period of deficiency. Other structures, such as the parafascicular nucleus of the thalamus, were more resistant and exhibited degeneration only after four periods of thiamine deprivation. Severe damage in the basal ganglia was infrequent and was associated with prolonged rather than multiple periods of deprivation. No parenchymal damage was found in the mammillary bodies or mediodorsal nucleus of the thalamus, suggesting that lesions in these prominent sites of damage in Wernicke\u2010Korsakoff disease develop only in the most advanced stages of thiamine deprivation. As a consequence of individual differences in susceptibility to thiamine deficiency, neurological symptoms and signs were more related to the profile of neural damage than to the number or duration of deprivation episodes.<\/jats:p>","DOI":"10.1002\/ana.410130404","type":"journal-article","created":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T17:46:39Z","timestamp":1124214399000},"page":"376-395","source":"Crossref","is-referenced-by-count":56,"title":["Intermittent thiamine deficiency in the rhesus monkey. I. Progression of neurological signs and neuroanatomical lesions"],"prefix":"10.1002","volume":"13","author":[{"given":"Ellen D.","family":"Witt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia S.","family":"Goldman\u2010Rakic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"749","volume-title":"Principles of Neurology","author":"Adams RD","year":"1977"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1946.02300230003001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1933.02240110058002"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1978.tb00528.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90179-4"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688148"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)36412-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700480202"},{"key":"e_1_2_1_10_2","volume-title":"Correlative neuroanatomy and functional neurology","author":"Chusid JG","year":"1979"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964146"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1961.00450110040005"},{"key":"e_1_2_1_13_2","first-page":"1849","article-title":"Corps mamillaires et syndrome Korsakoff. \u00c9tude anatomique de huit cas de syndrome de Korsakoff \u010forigine alcoolique sans alt\u00e9ration significative du cortex c\u00e9r\u00e9bral. I. \u00c9tude anatomo\u2010clinique","volume":"66","author":"Delay J","year":"1958","journal-title":"Presse Med"},{"key":"e_1_2_1_14_2","first-page":"1965","article-title":"Corps mamillaires et syndrome Korsakoff. \u00c9tude anatomique de huit cas de syndrome de Korsakoff \u010forigine alcoolique sans alt\u00e9ration significative du cortex c\u00e9r\u00e9bral. II. Tubercules mamillaires et m\u00e9canisme de la m\u00e9moire","volume":"66","author":"Delay J","year":"1958","journal-title":"Presse Med"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(47)91272-5"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/9.4.414"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.19.8.749"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.19.11.1135"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090404"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1941.02280220002001"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410060304"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01814665"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410040402"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.14.3.216"},{"key":"e_1_2_1_25_2","first-page":"2195","article-title":"Induction of thiamine inadequacy and polioencephalomalacia in adult sheep with amprolium","volume":"33","author":"Loew FM","year":"1972","journal-title":"Am J Vet Res"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/102.4.749"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1956.02330300015003"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.15.4.302"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1970.tb03692.x"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.27.3.239"},{"key":"e_1_2_1_31_2","volume-title":"The Thalamus of the Macaca Mulatta","author":"Olszewski J","year":"1952"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500110027005"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000148463"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.15288\/qjsa.1944.5.361","article-title":"Wernicke's disease: a clinical and pathological study of 42 cases","volume":"5","author":"Riggs HE","year":"1944","journal-title":"Q J Stud Alcohol"},{"key":"e_1_2_1_35_2","first-page":"129","article-title":"Effect of experimental thiamine deficiency on the nervous system of the rhesus monkey","volume":"48","author":"Rinehart JF","year":"1949","journal-title":"Arch Pathol"},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1182\/blood.V3.12.1453.1453","article-title":"Thiamine deficiency in the rhesus monkey: clinical, metabolic and hematologic observations","volume":"3","author":"Rinehart JF","year":"1948","journal-title":"Blood"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.10.1030"},{"key":"e_1_2_1_38_2","volume-title":"A stereotaxic atlas of the monkey brain (Macaca mulatta)","author":"Snider RS","year":"1961"},{"key":"e_1_2_1_39_2","first-page":"282","article-title":"La forme adult \u00e0 evolution chronique le \u013eencephalopathie n\u00e9crosante de Leigh: sa situation vis\u2010\u00e0\u2010vis des formes infanto\u2010juv\u00e9nile","volume":"71","author":"Solheid C","year":"1971","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510060052007"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1159\/000114952"},{"key":"e_1_2_1_42_2","volume-title":"Clinical Examinations in Neurology","author":"University of Minnesota Mayo Clinic and Mayo Foundation for Medical Education and Research. Department of Neurology and Department of Physiology and Biophysics","year":"1971"},{"key":"e_1_2_1_43_2","volume-title":"The Wernicke\u2010Korsakoff Syndrome","author":"Victor M","year":"1971"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.5.6.394"},{"key":"e_1_2_1_45_2","first-page":"265","article-title":"A study of thiamine deficiency in the monkey (Macaca mulatta)","volume":"4","author":"Waisman HA","year":"1944","journal-title":"Arch Biochem"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-193412000-00001"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(78)90012-6"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197807000-00004"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198107000-00008"},{"key":"e_1_2_1_50_2","volume-title":"Lehrbuch der Gehirnkrankheiten fur Aerzte und Studirende","author":"Wernicke C","year":"1881"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410030612"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130405"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410130404","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410130404","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T16:36:06Z","timestamp":1696005366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410130404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,4]]}},"alternative-id":["10.1002\/ana.410130404"],"URL":"https:\/\/doi.org\/10.1002\/ana.410130404","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,4]]}}}