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A muscle biopsy showed a \u201cragged red fiber\u201d myopathy with reduced muscle carnitine and mitochondrial enzymes. Computed tomographic brain scans showed cerebral white matter hypodensities and bilateral calcification of the basal ganglia. The mechanism for the folate deficiency and altered ratio of plasma to cerebrospinal fluid folate is unknown, but the deficiency may be responsive to replacement therapy.<\/jats:p>","DOI":"10.1002\/ana.410130620","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T13:49:40Z","timestamp":1104587380000},"page":"679-682","source":"Crossref","is-referenced-by-count":74,"title":["Kearns\u2010sayre syndrome with reduced plasma and cerebrospinal fluid folate"],"prefix":"10.1002","volume":"13","author":[{"given":"Richard J.","family":"Allen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"DiMauro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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