{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:14:35Z","timestamp":1760368475187},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7707,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1983,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurological syndromes are prominent in systemic lupus erythematosus, but the neuropathological mechanisms resulting in neurological dysfunction are unknown. We report a neuropathological study of the central nervous system in female NZB\/W F<jats:sub>1<\/jats:sub> mice, an animal model of systemic lupus erythematosus. NZB\/W mice were studied at 3, 5, 8, 12, and 14 months of age, and 36\u2010month\u2010old female C57B16N\/NIA mice were studied as aged controls. A lymphoproliferative process was identified in the central nervous system of 39% of 8\u2010 to 12\u2010month\u2010old and all 14\u2010month\u2010old NZB\/W mice. Infiltrates of lymphocytes and plasma cells were seen in subarachnoid, choroid plexus interstitial, and Virchow\u2010Robin spaces. Lymphoid cells occasionally infiltrated brain parenchyma or accumulated as nodular masses. Concomitant visceral lymphoid infiltration was noted in 14\u2010month\u2010old mice. Dense deposits were seen ultrastructurally in the basal lamina of brain parenchymal capillaries of 14\u2010month\u2010old NZB\/W mice. These dense deposits were similar in appearance to immune complexes described in glomerular basal lamina, and appeared concomitantly with an advanced lupus\u2010like glomerulopathy. Similar deposits were not observed in choroid plexus. The possible relevance of these neuropathological changes to human central nervous system lupus is discussed.<\/jats:p>","DOI":"10.1002\/ana.410140311","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T15:08:32Z","timestamp":1104592112000},"page":"325-332","source":"Crossref","is-referenced-by-count":28,"title":["Neuropathological features of a lupus\u2010like disorder in autoimmune mice"],"prefix":"10.1002","volume":"14","author":[{"given":"Richard A.","family":"Rudick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas 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