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Groups of patients with active central nervous system damage could be distinguished easily, although there was a small percentage of false positive reactions. The reactivity was most marked in the demyelinative, encephalitic, and stroke categories. A radioimmunoassay for proteolipid protein of proper sensitivity and specificity may prove to be a useful objective clinical measure of the presence and degree of disease activity in multiple sclerosis and other diseases.<\/jats:p>","DOI":"10.1002\/ana.410140510","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:02:06Z","timestamp":1104598926000},"page":"554-558","source":"Crossref","is-referenced-by-count":11,"title":["Immunoreactive myelin proteolipid protein\u2014like activity in cerebrospinal fluid and serum of neurologically impaired patients"],"prefix":"10.1002","volume":"14","author":[{"given":"John L.","family":"Trotter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy L.","family":"Wegescheide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Garvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1977.tb10420.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050608"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080104"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197612232952604"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(79)90127-X"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00852a042"},{"key":"e_1_2_1_8_2","first-page":"320","article-title":"A method for the electron microscopic study of cerebrospinal fluid sediment","volume":"29","author":"Herndon RM","year":"1970","journal-title":"J Neuropathol Exp Neurol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1967.00470300030007"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(78)90008-6"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1980.00500570019001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.10.1361"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(78)90168-4"},{"key":"e_1_2_1_14_2","first-page":"112","article-title":"Myelin proteolipid protein in sera and cerebrospinal fluid after damage to the central nervous system (abstract)","volume":"8","author":"Trotter JL","year":"1980","journal-title":"Ann Neurol"},{"key":"e_1_2_1_15_2","first-page":"59","article-title":"Myelin basic protein in cerebrospinal fluid and normal and pathological brains","volume":"9","author":"Trotter JL","year":"1978","journal-title":"Trans Am Soc Neurochem"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb01725.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.27.10.911"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070111"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410140510","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410140510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T01:56:17Z","timestamp":1697680577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410140510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,11]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1983,11]]}},"alternative-id":["10.1002\/ana.410140510"],"URL":"https:\/\/doi.org\/10.1002\/ana.410140510","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,11]]}}}