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Following treatment the percentage of T\u03b3 cells in both group I and group II patients decreased from above the mean normal control levels to below this level; OKT8 + cell numbers in group I became lower than in any of the control groups; the percentage of concanavalin A\u2010\u2010induced suppressor activity, which was initially normal, fell in group II and suggestively but not significantly in group I; and total blood lymphocytes in group I decreased from normal to below control levels. Other tests showed no significant changes with therapy. No significant difference in changes in clinical status were observed after one year in the treated patients compared with matched controls.<\/jats:p>","DOI":"10.1002\/ana.410140609","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:02:41Z","timestamp":1104598961000},"page":"656-661","source":"Crossref","is-referenced-by-count":0,"title":["Thymectomy\u2010induced decrease in T\u03b3 cells and OKT8+ cells in multiple sclerosis"],"prefix":"10.1002","volume":"14","author":[{"given":"John L.","family":"Trotter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard M.","family":"Gebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William F.","family":"Garvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen E.","family":"Rodey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196412242712601"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050406"},{"key":"e_1_2_1_4_2","first-page":"137","article-title":"Effect of Imuran therapy on in vitro immune function in multiple sclerosis (MS)","volume":"31","author":"Antel JP","year":"1981","journal-title":"Neurology (NY)"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.10.999"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92480-0"},{"key":"e_1_2_1_7_2","first-page":"1","article-title":"Evaluation of T cell subsets in myasthenia gravis using anti\u2010T cell monoclonal antibodies","volume":"45","author":"Berrih S","year":"1981","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_8_2","first-page":"1842","article-title":"Human B cell differentiation. 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