{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:08:01Z","timestamp":1791400081330,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7585,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Eight infants developed a progressive disorder of the central nervous system with bilateral spasticity and dystonia, acquired microcephaly, and a rapid course toward profound deterioration and death. All the patients had abnormal cerebrospinal fluid with mild but persistent lymphocytosis. Computed tomography showed various combinations of bilateral symmetrical calcifications in the basal ganglia, progressive brain atrophy, and deep white matter hypodensities, the first two being present in all families but not in every individual patient. The disorder is familial and probably genetic in origin, although some features, especially the pleocytosis, may erroneously suggest an inflammatory condition.<\/jats:p>","DOI":"10.1002\/ana.410150109","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T12:03:19Z","timestamp":1104580999000},"page":"49-54","source":"Crossref","is-referenced-by-count":433,"title":["A Progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis"],"prefix":"10.1002","volume":"15","author":[{"given":"J.","family":"Aicardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gouti\u00e8res","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"342","article-title":"Familial bilateral vascular calcification in the central nervous system","volume":"67","author":"Bruyn GW","year":"1964","journal-title":"Psychiatr Neurol Neurochir"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.11.61.1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.134.1.7350641"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.10.741"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-3338-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00344938"},{"key":"e_1_2_1_8_2","first-page":"162","volume-title":"Neuroradiology in Infants and Children","author":"Harwood\u2010Nash DC","year":"1976"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1192\/bjp.85.354.22","article-title":"Diffuse sclerosis with preserved myelin islands: a pathological report of a case with a note on cerebral involvement in Raynaud's disease","volume":"85","author":"Horanyi\u2010Hechst B","year":"1939","journal-title":"J Ment Sci"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195404000-00002"},{"key":"e_1_2_1_11_2","first-page":"703","volume-title":"Diseases of the Basal Ganglia. 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