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Carotid ligations and two hours of 8% oxygen environment in 7\u2010day\u2010old pups led to asymmetrical turning behavior, a 70% decrease in endogenous striatal dopamine levels, and a 125% increase in homovanillic acid (HVA) concentrations on the side of ligation. In contrast, hypoxia alone and total global ischemia alone were not associated with HVA level elevation. Elevation of HVA level with hypoxia\u2010ischemia showed a threshold effect between 1 and 1.5 hours, and this time course paralleled that for production of gross morphological changes in rats raised to maturity. The data suggest that dopamine release from striatal nerve terminals is associated with events causing brain injury during perinatal hypoxia\u2010ischemia. Tissue HVA in the animal model appears to be a quantitative marker for the effects of the insult on a population of nerve terminals.<\/jats:p>","DOI":"10.1002\/ana.410150407","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:08:31Z","timestamp":1104599311000},"page":"342-347","source":"Crossref","is-referenced-by-count":65,"title":["Effects of hypoxia\u2010ischemia on monoamine metabolism in the immature brain"],"prefix":"10.1002","volume":"15","author":[{"given":"Faye","family":"Silverstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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