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Removal of a parathyroid adenoma in one patient and three hyperplastic parathyroid glands in the other resulted in remission of the hyperparathroidism but left both patients with residual neurological damage. Postmortem examination of the second patient showed typical features of amyotrophic lateral sclerosis. The findings in these patients show that hyperparathyroidism may be associated with signs of severe central nervous system disease and that patients with unexplained neurological signs or symptoms should be checked for hyperparathyroidism.<\/jats:p>","DOI":"10.1002\/ana.410150509","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:08:50Z","timestamp":1104599330000},"page":"453-456","source":"Crossref","is-referenced-by-count":24,"title":["Severe neurological disease associated with hyperparathyroidism"],"prefix":"10.1002","volume":"15","author":[{"given":"Bernard M.","family":"Patten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Pages","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000115098"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-79-4-566"},{"key":"e_1_2_1_4_2","first-page":"1","article-title":"The parathyroid gland and its relation to diseases of the nervous system","volume":"32","author":"Bartter FC","year":"1953","journal-title":"Res Publ Assoc Res Nerv Ment Dis"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-4-575"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(56)90074-2"},{"key":"e_1_2_1_7_2","first-page":"288","volume-title":"Handbook of Clinical Neurology","author":"Bonduelle M","year":"1975"},{"key":"e_1_2_1_8_2","first-page":"1293","article-title":"On intracellular inclusions in familial amyotrophic lateral sclerosis","volume":"62","author":"Bunina TL","year":"1962","journal-title":"Zh Nevropatol Psikhiatr"},{"key":"e_1_2_1_9_2","first-page":"116","volume-title":"Amyotrophic Lateral Sclerosis","author":"Hirano A","year":"1979"},{"key":"e_1_2_1_10_2","first-page":"187","volume-title":"Amyotrophic Lateral Sclerosis","author":"Ikuta F","year":"1979"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1964.00460160057005"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197403000-00002"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91783-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-2-182"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800530402"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1961.03620100098014"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5625.230"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197912000-00019"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410150509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410150509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T21:39:00Z","timestamp":1697837940000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410150509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1984,5]]}},"alternative-id":["10.1002\/ana.410150509"],"URL":"https:\/\/doi.org\/10.1002\/ana.410150509","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5]]}}}