{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:47:22Z","timestamp":1782283642072,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7433,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1984,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A recent analysis of hyponatremic patients disclosed that those who were chronically hyponatremic prior to rapid correction subsequently developed central pontine myelinolysis. To test the view that chronicity of hyponatremia is a factor in myelinolysis, we studied a group of rats that were hyponatremic for 1 day and compared it with another group of animals maintained in a hyponatremic state for 3 days prior to the administration of hypertonic saline solution. The 3\u2010day hyponatremic rats developed more numerous and more severe demyelinative lesions than the 1\u2010day rats. The findings support the view that duration of hyponatremia is a factor in myelinolysis and that the electrolyte disturbance of chronically hyponatremic patients should be corrected cautiously and relatively slowly.<\/jats:p>","DOI":"10.1002\/ana.410150606","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:10:03Z","timestamp":1104599403000},"page":"544-547","source":"Crossref","is-referenced-by-count":76,"title":["Chronicity of hyponatremia as a factor in experimental myelinolysis"],"prefix":"10.1002","volume":"15","author":[{"given":"Michael D.","family":"Norenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Papendick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197603000-00002"},{"key":"e_1_2_1_3_2","first-page":"955","article-title":"Death or permanent neurologic disability despite correction of protracted hyponatremia","volume":"16","author":"Arieff AI","year":"1979","journal-title":"Kidney Int"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90822-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90575-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.3.1554"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.58.686.737"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jama.1982.03320290017021","article-title":"Hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone","volume":"247","author":"Decaux G","year":"1982","journal-title":"JAMA"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490070103013"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1960.00450050033005"},{"key":"e_1_2_1_11_2","first-page":"159","article-title":"Cell volume, pumps, and neurologic function: brain's adaptation to osmotic stress","volume":"53","author":"Fishman RA","year":"1974","journal-title":"Res Publ Assoc Nerv Ment Dis"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90261-0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-78-6-870"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105882"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7466381"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198201000-00007"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130303"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198105000-00067"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1983.04050020028004"},{"key":"e_1_2_1_20_2","volume-title":"Controversies in Nephrology and Hypertension","author":"Norenberg MD"},{"key":"e_1_2_1_21_2","unstructured":"NorenbergMD BellKP:Plasminogen activator and steroids in electrolyte\u2010induced myelinolysis. 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