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After 18 days the cells were exposed to radiolabeled iron. Total iron uptake and incorporation into ferritin were rapid and linear over four hours. The addition of either methylamine or ammonium chloride, both known blockers of transferrin\u2010iron release through their lysosomotropic properties, inhibited total iron uptake. Methylamine also inhibited the rate of ferritin\u2010iron incorporation, most likely by interfering with transferrin\u2010iron release. The data suggest that neuronal iron transport, much like that in other mammalian tissues, is transferrin mediated and that blockers of transferrin\u2010iron release may be of value in conditions in which there is brain iron overload.<\/jats:p>","DOI":"10.1002\/ana.410160113","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:10:45Z","timestamp":1104599445000},"page":"66-70","source":"Crossref","is-referenced-by-count":46,"title":["Iron uptake by mammalian cortical neurons"],"prefix":"10.1002","volume":"16","author":[{"given":"Kenneth F.","family":"Swaiman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valynda 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