{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:39:16Z","timestamp":1768340356325,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7311,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1984,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hereditary dysphasic dementia is described in terms of its clinicopathological, ultrastructural, and transmissibility characteristics. Its mode of inheritance is autosomal dominant, and its clinical manifestations of progressive dementia and severe dysphasic disturbances are expressed in late adulthood. Complete neuropathological examination of four patients reveals findings typical for Pick's disease (asymmetrical focal cerebral atrophy), Alzheimer's disease (profuse neuritic plaques), and paralysis agitans (neuronal depigmentation, depletion, and Lewy body formation in substantia nigra) in addition to a striking but nonspecific spongiform degeneration of superficial cortical layers. This unique combination of gross morphological and histopathological features qualifies hereditary dysphasic dementia as a distinct entity, but its precise relationship to the well\u2010recognized adult cortical dementias has been difficult to establish by conventional classification methods. This disorder and other unusual dementing illnesses may be best considered as part of a Pick\u2010Alzheimer spectrum of cortical neuronal degenerations.<\/jats:p>","DOI":"10.1002\/ana.410160407","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:15:10Z","timestamp":1104599710000},"page":"455-466","source":"Crossref","is-referenced-by-count":89,"title":["Hereditary dysphasic dementia and the Pick\u2010Alzheimer spectrum"],"prefix":"10.1002","volume":"16","author":[{"given":"John C.","family":"Morris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monroe","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty Q.","family":"Banker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1944.02290250033002"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02866241"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1949.02310100033003"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410070408"},{"key":"e_1_2_1_6_2","first-page":"175","volume-title":"Transactions of the American Neurological Association","author":"Cole M","year":"1979"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000114320"},{"key":"e_1_2_1_8_2","first-page":"811","volume-title":"Greenfield's Neuropathology","author":"Corsellis JAN","year":"1976"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6338589"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.13.10.811"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-195308000-00001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/105.3.443"},{"key":"e_1_2_1_13_2","first-page":"27","volume-title":"Dementia","author":"Hasse GR","year":"1977"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.9_Part_1.1209"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(79)90171-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1941.02280170092007"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1978.tb06886.x"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1972.00490120070008"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.23.4.334"},{"key":"e_1_2_1_20_2","first-page":"1385","volume-title":"Pathology of the Nervous System","author":"Jervis GA","year":"1971"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/104.1.61"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685366"},{"key":"e_1_2_1_23_2","first-page":"1221","volume-title":"Histology and Histopathology of the Nervous System","author":"Lindenberg R","year":"1982"},{"key":"e_1_2_1_24_2","first-page":"119","article-title":"The patho\u2010anatomical classification of morbus Alzheimer and morbus Pick","volume":"82","author":"Lindgren AGH","year":"1952","journal-title":"Acta Psychiatr Neurol Scand [Suppl]"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/101.2.333"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410110607"},{"key":"e_1_2_1_27_2","first-page":"231","article-title":"Demencias preseniles. 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