{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T19:39:14Z","timestamp":1769283554136,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7160,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Attentionl has recently been directed toward patients having a polyneuropathy IgM anti\u2010Myelin\u2010associated glycoprotein (anti\u2010MAG) antibody. The possibility of a pathogenetic role for the anti\u2010MAG antibody in the evolution of the polyneuropathy and in the development of central nervous system signs, including tremor and ataxia, remains unresolved. In 5 patients with this syndrome whose clinical courses were followed closely, in 1 of whom a complete postmortem examination of the nervous system was performed, we made the folowing obsercvations: (1) the anti\u2010MAG antibody did not localize to the compact layer of the myelin sheath in affected nerves, but did realize to areas of myelin splitting; (2) anti\u2010MAG antibody present in the sural nerve of an affected individual for 7 years was not associated with progressive pathology; (3) anti\u2010MAG antibody was not deposited in the central nervous system of an affected individual, although the antibody did bind to these same tissues in vitro; (4) deposition of anti\u2010MAG antibody observed at postmortem examination did not correlate with the degree of pathological change; and (5) study of the peripheral nervous system favored a primary axonal neuropathy with secondary demyelination.<\/jats:p>","DOI":"10.1002\/ana.410170305","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:21:09Z","timestamp":1104600069000},"page":"243-254","source":"Crossref","is-referenced-by-count":155,"title":["Polyneuropathy and IgM monoclonal gammopathy: Studies on the pathogenetic role of anti\u2010myelin\u2010associated glycoprotein antibody"],"prefix":"10.1002","volume":"17","author":[{"given":"J. R.","family":"Mendell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Sahenk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. N.","family":"Whitaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. D.","family":"Trapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Yates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Griggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H.","family":"Qurarles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.8.821"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1966.tb05453.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb12563.x"},{"key":"e_1_2_1_5_2","first-page":"195","article-title":"Manifestations neurologiques des gammopthies monoclonales","volume":"132","author":"Chazot G","year":"1976","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1182\/blood.V62.2.280.280","article-title":"Waldenstr\u00f6m's macroglobulinemia and peripheral neuropathy: a cllinical and immunologic study of 25 patients","volume":"62","author":"Dellagi K","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090611"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1971.tb05070.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.s1-6.1.54"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.4.1225"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1982.tb12578.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1978.00500310025005"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.7.617"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.11.1480"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.11.7139"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1056\/NEJM198009113031105","article-title":"Plasma cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral nerve myelin","volume":"303","author":"Latov N","year":"1983","journal-title":"N Engl J Med"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(83)90034-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1982.tb04529.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.11.1397"},{"key":"e_1_2_1_20_2","first-page":"A183","article-title":"Monoclonal IgM and peripheral neuropathy: studies on passive trasfer and anibody characterization","volume":"32","author":"Mendell JR","year":"1982","journal-title":"Neurology (Minneap)"},{"key":"e_1_2_1_21_2","first-page":"119","article-title":"Monoclonal IgM and peripheral neuropathy: relation of IgM binding to central and peripheral nervous system disease (abstract)","volume":"14","author":"Mednell JR","year":"1983","journal-title":"Ann Neurol"},{"key":"e_1_2_1_22_2","first-page":"256","article-title":"Specificity of mouse and human monoclonal antibodies to the myelin\u2010associated glycoprotien (MAG)","volume":"34","author":"Noble\u2010Orazio E","year":"1984","journal-title":"Neurology"},{"key":"e_1_2_1_23_2","first-page":"1310","article-title":"Uncompacted myelin lamellae in dysglobulinemia and neuropathy","volume":"51","author":"Ohnishi A","year":"1984","journal-title":"J Neurol Sci"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.25.10.980"},{"key":"e_1_2_1_25_2","first-page":"55","volume-title":"Myelin: Chemistry and Biology","author":"Quarles RH","year":"1980"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964417"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/106.1.169"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.1.19"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.2.179"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic trasfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and applications","volume":"76","author":"Towbin H","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.90.1.1"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.92.3.877"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90150-2"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410170305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410170305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T01:54:24Z","timestamp":1697766864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410170305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["10.1002\/ana.410170305"],"URL":"https:\/\/doi.org\/10.1002\/ana.410170305","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}