{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:53:17Z","timestamp":1774677197768,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7129,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A geographic isolate of tropical spastic paraparesis (TSP) in Tumaco, Colombia, is described. Fifity confirmed cases were identified (29 men, 21 women) with an estimated prevalence rario of 98 cases per 100, 000 population. Patients with identified cases ranged in age from 24 to75 years (mean, 46.5). TSP begins with burning feet, leg stiffness, spastic bladder, and, in men, impotence. Patients exhibited leg weakness, spasticity, hyperreflexia, and scissoring gait. Babinski, Chaddock, and Hoffmann signs could elicited. Ankle reflexes and vibratory sensation of the feet were decresed. Intellectual function, coordination, and cranial nerves remained normal. TSP is slowly progressive disorder but so far there have been no deaths from it. Forth cases in this report began between 1971 and 1980; the earliest documented case began in 1952. Living conditions and occupations of the patients were typical for the region. Yaws had occured in 74% of confirmed cases. No likely etiological neurotoxix or nutritional factors identified. TSP aslo has been described in India, Africa, the Seychelles, and Jamaica.<\/jats:p>","DOI":"10.1002\/ana.410170410","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:22:18Z","timestamp":1104600138000},"page":"361-365","source":"Crossref","is-referenced-by-count":55,"title":["Tropical spastic paraparesis: A neuroepidemiological study in Colombia"],"prefix":"10.1002","volume":"17","author":[{"given":"Gustavo C.","family":"Rom\u00e1n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia N.","family":"Rom\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce S.","family":"Schoenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"308","volume-title":"Memorias Seminario Estudios Cientificos sobre el Impacto humano en el Ecosistema de los Manglares","author":"Barreto P","year":"1980"},{"key":"e_1_2_1_3_2","first-page":"27","volume-title":"La mortalidad en Colombia: 1970\u20131982. Estudio Na\u00e7 de Salud","author":"Bayona A","year":"1982"},{"key":"e_1_2_1_4_2","first-page":"592","article-title":"Unexplained spastic myelopathy: 41 cases in a non\u2010European hospital","volume":"37","author":"Cosnett JE","year":"1965","journal-title":"S Afr Med J"},{"key":"e_1_2_1_5_2","first-page":"147","article-title":"A neuropathic syndrome of uncertain origin","volume":"5","author":"Cruickshank EK","year":"1956","journal-title":"West Indian Med J"},{"key":"e_1_2_1_6_2","first-page":"5","article-title":"Paraplegia in the islands of the Indian Ocean","volume":"1","author":"Kelly R","year":"1982","journal-title":"Afr Neurol Sci"},{"key":"e_1_2_1_7_2","first-page":"509","volume-title":"Neurological Epidemiology: Principles and Clinical Applications(Vol 19, Advances in neurology)","author":"Kondo K","year":"1978"},{"key":"e_1_2_1_8_2","first-page":"13","volume-title":"Slow, Latent and Temperate Infections","author":"Kurland LT","year":"1965"},{"key":"e_1_2_1_9_2","first-page":"69","volume-title":"Neurologival Epidemiological Epidemiology: Principles and Clinical Applications (Vol 19, Adcances in Neurology)","author":"Kurland LT","year":"1978"},{"key":"e_1_2_1_10_2","first-page":"1","volume-title":"Clinical Neurology","author":"Kuttzke JF","year":"1973"},{"key":"e_1_2_1_11_2","first-page":"294","article-title":"Pian Y campa\u00f1a antipi\u00e1nica en Colombia","volume":"24","author":"L\u00f3pez Narv\u00e1ez G","year":"1956","journal-title":"Rev Rac Med UN (Colombia)"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(69)90067-7"},{"key":"e_1_2_1_13_2","first-page":"244","article-title":"Teh relation of treponematosis to idiopathic neuropathies in Jamaica","volume":"9","author":"Montgomery RD","year":"1960","journal-title":"West Indian Med J"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/87.3.425"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/91.2.215"},{"key":"e_1_2_1_16_2","first-page":"2466","volume-title":"Pathology of the Nervous system","author":"Robertson WB","year":"1972"},{"key":"e_1_2_1_17_2","first-page":"36","article-title":"The clinical features and aetiology of the neuropathic syndrome in Jamaica","volume":"14","author":"Rodgers PEB","year":"1965","journal-title":"West Indian Med J"},{"key":"e_1_2_1_18_2","first-page":"226","article-title":"Neuro\u2010opthalmological study of late yaws and pinta. II. The Caracas project","volume":"47","author":"Smith JL","year":"1971","journal-title":"Br J Vener Dis"},{"key":"e_1_2_1_19_2","volume-title":"Tropical Neurology","author":"Spillane JD","year":"1973"},{"key":"e_1_2_1_20_2","first-page":"357","article-title":"Untersuchugen zur neurotoxizitaet von Arbeitzztoffen. II. Messens der motorishcen und sensorischen Nervenleitseschwindiskeit bei beruflich Pentachlorophenol\u2010belasteten Personen","volume":"48","author":"Triebis G","year":"1981","journal-title":"Int Arch Occup Environ health"},{"key":"e_1_2_1_21_2","first-page":"689","article-title":"Unexplained spastic paraplegia","volume":"63","author":"Wallace ID","year":"1983","journal-title":"S Afr Med J"},{"key":"e_1_2_1_22_2","volume-title":"The Pacific Lowlands of Colombia: A Negroid area of the American Tropics","author":"West RC","year":"1957"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.25100\/cm.v12i3.6013","article-title":"Paraparesia esp\u00e1stica del Pac\u00edo","volume":"12","author":"Zaninovic V","year":"1981","journal-title":"Colombia M\u00e9"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410170410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410170410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410170410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,22]],"date-time":"2024-12-22T05:45:42Z","timestamp":1734846342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410170410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,4]]}},"alternative-id":["10.1002\/ana.410170410"],"URL":"https:\/\/doi.org\/10.1002\/ana.410170410","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,4]]}}}