{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:48:32Z","timestamp":1791182912716,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,10,7]],"date-time":"2004-10-07T00:00:00Z","timestamp":1097107200000},"content-version":"vor","delay-in-days":7129,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Neurology"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Brain computed tomographic scan of 60 patients with early\u2010onset Alzheimer's disease (mean age, 60.7 years) were compared awith those of age\u2010 and sex\u2010matched control subjects. Computed tomographic analysis included standard ventricular measurements as well as subjectice ratings of ventriculat sulcal size. These indiceswere correlated with the results of a battery of neuropsychological tests and electroencephalographic findings.<\/jats:p><jats:p>Linear measurements of ventricular size were significantly greater in the patients with Alzheimer's disease than in the age\u2010matched control group (<jats:italic>p<\/jats:italic>&lt;0.0005). Using subjective appraisal of ventricular and sulcal size, the neuroradiologist noted anmormalities significantly more often in patients than in controls (<jats:italic>p<\/jats:italic>&lt;0.0005). Linear measurements of ventricular size correlated significantly (<jats:italic>p<\/jats:italic>&lt;0.05) with the severity of aphasia and dementia and the presence of electroemcephalographic abnormalities. There was, however, no correlation between the subjective judgement of cortical atrophy and degree impairment as measured byneuropsychological tests. The fidings in this study demonstrate the usefulness of computed tomographic imaging Alzheimer's disease of early onset.<\/jats:p>","DOI":"10.1002\/ana.410170420","type":"journal-article","created":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T17:22:18Z","timestamp":1104600138000},"page":"407-410","source":"Crossref","is-referenced-by-count":35,"title":["Early\u2010onset Alzheimer's disease: An analysis of CT findings"],"prefix":"10.1002","volume":"17","author":[{"given":"Burton P.","family":"Drayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Heyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,10,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700046730"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.26.11.1011"},{"key":"e_1_2_1_4_2","first-page":"89","article-title":"Qualitative indexes of computed tomography in dementia and normal aging","volume":"138","author":"Brinkman SD","year":"1981","journal-title":"Radilogy"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(80)90027-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-1039-6_30"},{"key":"e_1_2_1_7_2","first-page":"1138","article-title":"Qualitative indexes of computed tomography","volume":"29","author":"Earnes MP","year":"1979","journal-title":"Neurology (NY)"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.144.3.7100467"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1044\/jshd.1401.09"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140503"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/116.1.85"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.140.6.566"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.136.3.256"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.29.9_Part_1.1273"},{"key":"e_1_2_1_16_2","first-page":"706","article-title":"CT assessment of CSF spaces in the brain in demented and nondemented patients over 60 years of age","volume":"4","author":"Kohlmeyer K","year":"1983","journal-title":"AJNR"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.39.10.986"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(70)90063-8"}],"container-title":["Annals of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fana.410170420","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ana.410170420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T01:51:41Z","timestamp":1697766701000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.410170420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,4]]}},"alternative-id":["10.1002\/ana.410170420"],"URL":"https:\/\/doi.org\/10.1002\/ana.410170420","archive":["Portico"],"relation":{},"ISSN":["0364-5134","1531-8249"],"issn-type":[{"value":"0364-5134","type":"print"},{"value":"1531-8249","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,4]]}}}